Chondroitin sulfate proteoglycans protect cultured rat's cortical and hippocampal neurons from delayed cell death induced by excitatory amino acids

M Okamoto, S Mori, M Ichimura, H Endo - Neuroscience letters, 1994 - Elsevier
Protective effects of chondroitin sulfate proteoglycans (CSPGs) from rat's brain against
delayed cell death induced by excitatory amino acids were examined in cultured neurons of …

A protective action of chondroitin sulfate proteoglycans against neuronal cell death induced by glutamate

M Okamoto, S Mori, H Endo - Brain research, 1994 - Elsevier
The role of chondroitin sulfate proteoglycans (CSPGs) on excitotoxic cell death and long-
term survival of neurons were investigated in primary cultured neurons of the rat cortex …

A highly sulfated chondroitin sulfate preparation, CS‐E, prevents excitatory amino acid‐induced neuronal cell death

Y Sato, K Nakanishi, Y Tokita… - Journal of …, 2008 - Wiley Online Library
J. Neurochem.(2008) 104, 1565–1576. Abstract Chondroitin sulfate (CS) is a major
microenvironmental molecule in the CNS, and there have been few reports about its …

Chondroitin sulfate reduces cell death of rat hippocampal slices subjected to oxygen and glucose deprivation by inhibiting p38, NFκB and iNOS

MD Martín-de-Saavedra, L del Barrio, N Canas… - Neurochemistry …, 2011 - Elsevier
The glycosaminoglycan chondroitin sulfate (CS) is a major constituent of the extracellular
matrix of the central nervous system where it can constitute part of the perineuronal nets …

Neuroprotective effect of pentosan polysulphate on ischemia-related neuronal death of the hippocampus

Y Sakurai-Yamashita, H Kinugawa, M Niwa - Neuroscience letters, 2006 - Elsevier
Pentosan polysulphate (PPS) negatively charged sulphated glycosaminoglycan was studied
in ischemia-related hippocampal neuronal death and compared with a low molecular weight …

A disaccharide derived from chondroitin sulphate proteoglycan promotes central nervous system repair in rats and mice

A Rolls, H Avidan, L Cahalon, H Schori… - European Journal of …, 2004 - Wiley Online Library
Chondroitin sulphate proteoglycan (CSPG) inhibits axonal regeneration in the central
nervous system (CNS) and its local degradation promotes repair. We postulated that the …

Core proteins of soluble chondroitin sulfate proteoglycans purified from the rat brain block the cell cycle of PC12D cells

R Katoh‐Semba, A Oohira - Journal of cellular physiology, 1993 - Wiley Online Library
The effects of soluble chondroitin sulfate proteoglycans (CSPGs) purified from the rat brain
on proliferation of and neurite outgrowth from PC12D cells (Katoh-Semba et al., J Neurosci …

Protective properties of neural extracellular matrix

A Suttkus, M Morawski, T Arendt - Molecular neurobiology, 2016 - Springer
The extracellular matrix (ECM) of the central nervous system (CNS) occupies a large part of
the neural tissue. It serves a variety of functions ranging from support of cell migration and …

Changes in the amounts of chondroitin sulfate proteoglycans in rat brain after neonatal hypoxia‐ischemia

F Matsui, H Kakizawa, M Nishizuka… - Journal of …, 2005 - Wiley Online Library
Chondroitin sulfate proteoglycans have been shown to participate in the pathogenesis of
neuronal damages in the injured adult central nervous system (CNS). Upregulated …

Chondroitin sulphate proteoglycans in the rat brain: candidates for axon barriers of sensory neurons and the possible modification by laminin of their actions

R Katoh‐Semba, M Matsuda, K Kato… - European Journal of …, 1995 - Wiley Online Library
The addition of chondroitin sulphate proteoglycans (CSPGs), purified from the rat brain, to
the culture medium of PC12D cells inhibited their proliferation and neurite outgrowth …