Alphaviruses are enveloped single stranded RNA viruses, which as gene therapy vectors
provide high-level transient gene expression. Semliki Forest virus (SFV), Sindbis virus (SIN) …

Alphaviruses synthesize large amounts of both genomic and subgenomic RNA in infected
cells, but usually only the genomic RNA is packaged. This implies the existence of an …

Infection of BHK cells by Sindbis virus leads to rapid inhibition of host cell protein synthesis
and cytopathic effects (CPE). We have been studying these events to determine whether the …

Sindbis virus (SINV) is an enveloped, mosquito-borne alphavirus. Here we generated and
characterized a fluorescent protein-tagged (FP-tagged) SINV and found that the presence of …

Sindbis virus was used as a self-amplifying eukaryotic expression vector. A recombinant
cDNA genome of this (+)-strand RNA virus was placed under the transcriptional control of a …

Clearance of infectious Sindbis virus from neurons is mediated by antibody to the E2
glycoprotein. Properties of the antibody important for downregulation of Sindbis virus …

ABSTRACT Infection of adult 129 Sv/Ev mice with consensus Sindbis virus strain TR339 is
subclinical due to an inherent restriction in early virus replication and viremic dissemination …

The baculovirus-insect cell expression system is well-suited for recombinant glycoprotein
production because baculovirus vectors can provide high levels of expression and insect …

Antibodies directed to Sindbis virus (SV) envelope protein E2 are able to control virus
replication in vivo and in persistently infected cultures of neurons in vitro. We investigated …

We have constructed an orally infectious Sindbis virus, ME2/5′ 2J/GFP, that expresses
green fluorescent protein (GFP) in the midgut of Aedes aegypti and in other tissues as the …