Adenosine and ATP modulate cellular and tissue functions via specific P1 and P2 receptors,
respectively. Although, in general, adenosine inhibits excitability and ATP functions as an …

Adenosine and its endogenous precursor ATP are main components of the purinergic
system that modulates cellular and tissue functions via specific adenosine and ATP …

Adenosine and ATP/UTP are main components of the purinergic system that modulate
cellular and tissue functions via specific adenosine and P2 receptors, respectively. Here, we …

It is now well accepted that G protein-coupled receptors (GPCRs) can be directly associated,
as either homo-or hetero-oligomers, to alter their functions. G protein-coupled purinergic …

In the rat brain, a heteromeric association between adenosine A1 and purinergic P2Y1
receptors has been demonstrated. It is suggested that this association plays an important …

Background Purines such as adenosine and ATP are now generally recognized as the
regulators of many physiological functions, such as neurotransmission, pain, cardiac …

Abstract Adenosine A 1 receptors (A 1 R) are able to form a heteromeric complex with P2Y 1
receptors (P2Y 1 R) that generates A 1 R with P2Y 1 R-like agonistic pharmacology. A …

The aim of this paper was to check the possible interaction of two of the four purinergic P1
receptors, the A2A and the A3. Discovery of the A2A–A3 receptor complex was achieved by …

Adenosine and ATP, via their specific P1 and P2 receptors, modulate a wide variety of
cellular and tissue functions, playing a neuroprotective or neurodegenerative role in brain …

The medicinal chemistry and pharmacology of the four subtypes of adenosine receptors
(ARs) and the eight subtypes of P2Y receptors (P2YRs, activated by a range of purine and …