How organs are shaped to specific forms is a fundamental issue in developmental biology.
To address this question, we used the repetitive, periodic pattern of feather morphogenesis …

Sonic hedgehog (Shh) signalling controls integrated specification of digit pattern and growth
in the chick wing but downstream gene networks remain to be unravelled. We analysed 3D …

Applications of mathematical models to developmental biology have provided helpful insight
into various subfields, ranging from the patterning of animal skin to the development of …

Gap junctional communication is important for embryonic morphogenesis. However, the
factors regulating the spatial properties of small molecule signal flows through gap junctions …

In the classical model of chick wing digit-patterning, the polarizing region—a group of cells
at the posterior margin of the early bud—produces a morphogen gradient, now known to be …

The role of a boundary in pattern formation from a homogenous state in Turing's reaction–
diffusion equations is important, particularly when the domain size is comparable to the …

In vivo profiling of signal-directed gene expression patterns is a major bottleneck in studying
developmental biology. A signal molecule initiates its specific gene expression pattern …

Developing tissues can self-organize into a variety of patterned structures through the
stabilization of stochastic fluctuations in their molecular and cellular properties. While …

Periodic patterning is widespread in development and can be modelled by reaction-diffusion
(RD) processes. However, minimal two-component RD descriptions are vastly simpler than …

Formation of the primitive streak is one of the key events in the early development of amniote
embryos. The streak is the site where during gastrulation the mesendoderm cells ingress to …