Serotonin is an important neurohormonal factor that has been implicated in cardiovascular
function. It can regulate vascular tone, act directly on cardiomyocytes and stimulate …

Cardiovascular diseases and depression are significant health burdens and increasing
evidence suggests a causal relationship between them. The incidence of depression among …

Serotonin acts solely via 5-HT4-receptors to control human cardiac contractile function. The
effects of serotonin via 5-HT4-receptors lead to positive inotropic and chronotropic effects, as …

This review focuses on new insights provided by gene-modified animals into the
cardiovascular pharmacology of serotonin. During their development, mice mutant for …

The major target for circulating serotonin (released from aggregating platelets) appears to
be the blood vessel wall (although little evidence is available), suggesting a role for the …

Pleiotropic effects of serotonin (5-HT) in the cardiovascular system are well documented.
However, it remains to be elucidated, whether 5-HT is present in adult mammalian …

The present article deals with the pathophysiological role of serotonin in cardiovascular
disease and in other disorders that are accompanied by cardiovascular pathophysiological …

Selective serotonin reuptake inhibitors (SSRIs) are a heterogeneous group of new
antidepressants that cause a well documented acquired but reversible serotonin deficiency …

Serotonin is a naturally occurring vasoactive substance that has diverse cardio-
physiological effects. These effects can be explained by the existence of serotonin receptor …

Serotonin exerts complex effects in the cardiovascular system, including hypotension or
hypertension, vasodilatation or vasoconstriction, and/or bradycardia or tachycardia; the …