Deficient serotonin neurotransmission and depression-like serotonin biomarker alterations in tryptophan hydroxylase 2 (Tph2) loss-of-function mice
JPR Jacobsen, WB Siesser, BD Sachs, S Peterson… - Molecular …, 2012 - nature.com
Probably the foremost hypothesis of depression is the 5-hydroxytryptamine (5-HT, serotonin)
deficiency hypothesis. Accordingly, anomalies in putative 5-HT biomarkers have repeatedly …
deficiency hypothesis. Accordingly, anomalies in putative 5-HT biomarkers have repeatedly …
The 5-HT deficiency theory of depression: perspectives from a naturalistic 5-HT deficiency model, the tryptophan hydroxylase 2Arg439His knockin mouse
JPR Jacobsen, IO Medvedev… - … Transactions of the …, 2012 - royalsocietypublishing.org
A decreased level of brain 5-hydroxytryptamine (5-HT) has been theorized to be a core
pathogenic factor in depression for half a century. The theory arose from clinical …
pathogenic factor in depression for half a century. The theory arose from clinical …
Genetic disruption of both tryptophan hydroxylase genes dramatically reduces serotonin and affects behavior in models sensitive to antidepressants
KV Savelieva, S Zhao, VM Pogorelov, I Rajan, Q Yang… - PloS one, 2008 - journals.plos.org
The neurotransmitter serotonin (5-HT) plays an important role in both the peripheral and
central nervous systems. The biosynthesis of serotonin is regulated by two rate-limiting …
central nervous systems. The biosynthesis of serotonin is regulated by two rate-limiting …
Exaggerated aggression and decreased anxiety in mice deficient in brain serotonin
V Mosienko, B Bert, D Beis, S Matthes, H Fink… - Translational …, 2012 - nature.com
Serotonin is a major neurotransmitter in the central nervous system (CNS). Dysregulation of
serotonin transmission in the CNS is reported to be related to different psychiatric disorders …
serotonin transmission in the CNS is reported to be related to different psychiatric disorders …
Brain 5-HT deficiency increases stress vulnerability and impairs antidepressant responses following psychosocial stress
Brain serotonin (5-HT) deficiency and exposure to psychosocial stress have both been
implicated in the etiology of depression and anxiety disorders, but whether 5-HT deficiency …
implicated in the etiology of depression and anxiety disorders, but whether 5-HT deficiency …
Tryptophan hydroxylase 2 knockout male rats exhibit a strengthened oxytocin system, are aggressive, and are less anxious
X Meng, J Grandjean, G Sbrini, P Schipper… - ACS Chemical …, 2022 - ACS Publications
The central serotoninergic system is critical for stress responsivity and social behavior, and
its dysregulations have been centrally implicated in virtually all neuropsychiatric disorders …
its dysregulations have been centrally implicated in virtually all neuropsychiatric disorders …
Mice genetically depleted of brain serotonin do not display a depression-like behavioral phenotype
M Angoa-Pérez, MJ Kane, DI Briggs… - ACS chemical …, 2014 - ACS Publications
Reductions in function within the serotonin (5HT) neuronal system have long been proposed
as etiological factors in depression. Selective serotonin reuptake inhibitors (SSRIs) are the …
as etiological factors in depression. Selective serotonin reuptake inhibitors (SSRIs) are the …
Tryptophan hydroxylase 2 as a therapeutic target for psychiatric disorders: Focus on animal models
EA Kulikova, AV Kulikov - Expert Opinion on Therapeutic Targets, 2019 - Taylor & Francis
ABSTRACT Introduction: Tryptophan hydroxylase 2 (TPH2) is the key, rate-limiting enzyme
of serotonin (5-HT) synthesis in the brain. Some polymorphic variants of the human Tph2 …
of serotonin (5-HT) synthesis in the brain. Some polymorphic variants of the human Tph2 …
Brain-specific conditional and time-specific inducible Tph2 knockout mice possess normal serotonergic gene expression in the absence of serotonin during adult life
C Kriegebaum, NN Song, L Gutknecht, Y Huang… - Neurochemistry …, 2010 - Elsevier
Several lines of evidence implicate a dysregulation of tryptophan hydroxylase (TPH)-
dependent serotonin (5-HT) synthesis in emotional behaviour and stress, and point to its …
dependent serotonin (5-HT) synthesis in emotional behaviour and stress, and point to its …
Adaptive changes in serotonin metabolism preserve normal behavior in mice with reduced TPH2 activity
V Mosienko, S Matthes, N Hirth, D Beis, M Flinders… - …, 2014 - Elsevier
Polymorphisms in the TPH2 gene coding for the serotonin synthesizing enzyme in the brain
are considered as risk factors associated with depression and anxiety in humans. However …
are considered as risk factors associated with depression and anxiety in humans. However …