Interleukin-10 Increases Th1 Cytokine Production and Cytotoxic Potential in Human Papillomavirus-Specific CD8+ Cytotoxic T Lymphocytes

AD Santin, PL Hermonat, A Ravaggi, S Bellone… - Journal of …, 2000 - Am Soc Microbiol
Interleukin-10 (IL-10) is widely known as an immunosuppressive cytokine by virtue of its
ability to inhibit macrophage-dependent antigen presentation, T-cell proliferation, and Th1 …

[HTML][HTML] Interleukin-10 production by tumor infiltrating macrophages plays a role in Human Papillomavirus 16 tumor growth

A Bolpetti, JS Silva, LL Villa, AP Lepique - BMC immunology, 2010 - Springer
Abstract Background Human Papillomavirus, HPV, is the main etiological factor for cervical
cancer. Different studies show that in women infected with HPV there is a positive correlation …

The role of interleukin 10 in human papilloma virus infection and progression to cervical carcinoma

FCB Berti, APL Pereira, GCM Cebinelli… - Cytokine & growth factor …, 2017 - Elsevier
Abstract Although Human Papillomavirus (HPV) exerts a vital influence on cervical
carcinogenesis, other factors influence the development of a squamous intraepithelial lesion …

In Vivo Expression of Immunosuppressive Cytokines in Human Papillomavirus-Transformed Cervical Cancer Cells

JM Alcocer-González, J Berumen… - Viral …, 2006 - liebertpub.com
Genital human Papillomavirus infection is common and only a minor fraction of infected
subjects develop progressing cervical epithelial lesions or cancer. Bypassing local immune …

IL-17 suppresses immune effector functions in human papillomavirus-associated epithelial hyperplasia

C Gosmann, SR Mattarollo, JA Bridge… - The Journal of …, 2014 - journals.aai.org
Persistent infection with high-risk human papillomaviruses (HPV) causes epithelial
hyperplasia that can progress to cancer and is thought to depend on immunosuppressive …

Both E6 and E7 oncoproteins of human papillomavirus 16 inhibit IL-18-induced IFN-γ production in human peripheral blood mononuclear and NK cells

SJ Lee, YS Cho, MC Cho, JH Shim, K Lee… - The journal of …, 2001 - journals.aai.org
Cervical carcinoma is the predominant cancer among malignancies in women throughout
the world, and human papillomavirus (HPV) 16 is the most common agent linked to human …

Local immunosuppression induced by high viral load of human papillomavirus: characterization of cellular phenotypes producing interleukin‐10 in cervical neoplastic …

TTM Prata, CM Bonin, AMT Ferreira… - …, 2015 - Wiley Online Library
A specific immune response to human papillomavirus (HPV) in the cervical
microenvironment plays a key role in eradicating infection and eliminating mutated cells …

Cervical concentrations of interleukin-10 and interleukin-12 do not correlate with plasma levels

PE Castle, A Hildesheim, FP Bowman… - Journal of clinical …, 2002 - Springer
Human papillomavirus (HPV) infects the transformation zone of the cervix and is the primary
cause of cervical cancer. The infection is localized to the cervix and mucosal immunity is …

Interleukin-6 and interleukin-6 soluble receptor regulate proliferation of normal, human papillomavirus-immortalized, and carcinoma-derived cervical cells in vitro.

M Iglesias, GD Plowman… - The American journal of …, 1995 - ncbi.nlm.nih.gov
A variety of sexually transmitted diseases frequently accompany infection with human
papillomavirus and stimulate inflammation of the cervical mucosa. Inflammation and cell …

Activation of the interleukin‐32 pro‐inflammatory pathway in response to human papillomavirus infection and over‐expressionof interleukin‐32 controls the …

S Lee, JH Kim, H Kim, JW Kang, SH Kim, Y Yang… - …, 2011 - Wiley Online Library
High‐risk variants of human papillomavirus (HPV) induce cervical cancer by persistent
infection, and are regarded as the principal aetiological factor in this malignancy. The pro …