THE 10TH ANNIVERSARY of the report of the first animal cloned from an adult cell (Wilmut
et al., 1997) is an excellent time to look back, and to look forward. The ability to clone …

Restoring nuclear totipotency in differentiated somatic cells following nuclear transfer, to
produce healthy cloned animals, remains remarkable but highly inefficient and prone to …

Availability of suitable organs for transplantation remains of major concern and projections
indicate that the problem will continue to increase. Therefore, alternatives to the use of …

Although mouse embryonic stem cells have been used widely for over a decade as an
important tool for introducing precise genetic modification into the genome, demonstrating …

Somatic cell nuclear transfer (SCNT), popularly called “animal cloning (AC),” is the only
assisted reproductive technique that allows reprogramming of a differentiated somatic cell …

Nuclear transfer (NT) is a procedure by which genetically identical individuals can be
created. The applications of these NT techniques will be in agriculture, biomedicine, and …

ABREAKTHROUGH was made by Wilmut and his colleagues in 1996. A sheep named Dolly
was successfully cloned from an adult somatic cell (Wilmut et al., 1997). In this experiment …

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In contrast to the highly developed genetic modification systems available for manipulating
the mouse genome, at this time only simple gain of function modifications can be undertaken …

NUCLEAR TRANSFER is a procedure by which genetically identical individuals can be
created. The applications of these techniques for nuclear transfer will be in agricultural …