Endogenous estrogens protect from coronary artery disease in premenopausal women, but
the mechanisms involved are only partly understood. This study investigated whether …

Estrogen exerts protective effects against cardiovascular diseases in premenopausal
women, but is associated with an increased risk of both coronary heart disease and stroke in …

Premenopausal females have a lower incidence of cardiovascular disease than their male
counterparts, but the mechanism is unclear. Estrogen has been thought to signal through …

Estrogens can either relax or contract arteries via rapid, nongenomic mechanisms involving
classic estrogen receptors (ER). In addition to ERα and ERβ, estrogen may also stimulate G …

In premenopausal women, endogenous estrogens are associated with reduced prevalence
of arterial hypertension, coronary artery disease, myocardial infarction, and stroke. Clinical …

Endogenous estrogens are important regulators of cardiovascular homeostasis in
premenopausal women and delay the development of hypertension and coronary artery …

Activation of GPER exerts a protective effect in hypertension and ischemia-reperfusion
models and relaxes arteries in vitro. However, our understanding of the mechanisms of …

This study investigated the contribution of estrogen receptors (ERs) α and β for epicardial
coronary artery function, vascular NO bioactivity, and superoxide (O2−) formation. Porcine …

Compared with age-matched men, premenopausal women are largely protected from
coronary artery disease, a difference that is lost after menopause. The effects of oestrogens …

We found that the selective stimulation of the intracellular, transmembrane G protein–
coupled estrogen receptor (GPER), also known as GPR30, acutely lowers blood pressure …