A distinct region of the MGMT CpG island critical for transcriptional regulation is preferentially methylated in glioblastoma cells and xenografts
DS Malley, RA Hamoudi, S Kocialkowski… - Acta …, 2011 - Springer
Abstract O 6-Methylguanine-DNA methyltransferase (MGMT) is a DNA repair protein that
removes alkyl DNA adducts such as those induced by alkylating agents. Loss of MGMT …
removes alkyl DNA adducts such as those induced by alkylating agents. Loss of MGMT …
Inactivation of the DNA Repair Gene O6-Methylguanine-DNA Methyltransferase by Promoter Hypermethylation is a Common Event in Primary Human Neoplasia
The DNA repair protein O 6-methylguanine DNA methyltransferase (MGMT) removes alkyl
adducts from the O 6 position of guanine. MGMT expression is decreased in some tumor …
adducts from the O 6 position of guanine. MGMT expression is decreased in some tumor …
Inactivation of the DNA-Repair Gene MGMT and the Clinical Response of Gliomas to Alkylating Agents
M Esteller, J Garcia-Foncillas, E Andion… - … England Journal of …, 2000 - Mass Medical Soc
Background The DNA-repair enzyme O 6-methylguanine-DNA methyltransferase (MGMT)
inhibits the killing of tumor cells by alkylating agents. MGMT activity is controlled by a …
inhibits the killing of tumor cells by alkylating agents. MGMT activity is controlled by a …
Attenuation of O 6-methylguanine-DNA methyltransferase activity and mRNA levels by cisplatin and temozolomide in Jurkat cells
S D'Atri, G Graziani, PM Lacal, V Nisticò… - … of Pharmacology and …, 2000 - ASPET
The DNA repair protein O 6-methylguanine-DNA methyltransferase (MGMT) is important in
cellular resistance to certain alkylating antitumor agents such as the methylating drug …
cellular resistance to certain alkylating antitumor agents such as the methylating drug …
MGMT: key node in the battle against genotoxicity, carcinogenicity and apoptosis induced by alkylating agents
B Kaina, M Christmann, S Naumann, WP Roos - DNA repair, 2007 - Elsevier
O6-methylguanine-DNA methyltransferase (MGMT) plays a crucial role in the defense
against alkylating agents that generate, among other lesions, O6-alkylguanine in DNA …
against alkylating agents that generate, among other lesions, O6-alkylguanine in DNA …
The prognostic value of MGMT promoter methylation in glioblastoma: a meta‐analysis of clinical trials
MM Binabaj, A Bahrami, S ShahidSales… - Journal of cellular …, 2018 - Wiley Online Library
The DNA repair protein O6‐Methylguanine‐DNA methyltransferase (MGMT) is suggested to
be associated with resistance to alkylating agents such as Temozolomide which is being …
be associated with resistance to alkylating agents such as Temozolomide which is being …
Expression and Prognostic Significance ofO 6-Methylguanine-DNA Methyltransferase in Hepatocellular, Gastric, and Breast Cancers
S Matsukura, K Miyazaki, H Yakushiji, A Ogawa… - Annals of surgical …, 2001 - Springer
Abstract Background: O 6-Methylguanine-DNA methyltransferase MGMT is an enzyme that
repairs O 6-methylguanine, a promutagenic DNA base damaged by endogenous and …
repairs O 6-methylguanine, a promutagenic DNA base damaged by endogenous and …
MGMT promoter methylation in plasma of glioma patients receiving temozolomide
V Fiano, M Trevisan, E Trevisan, R Senetta… - Journal of neuro …, 2014 - Springer
Promoter methylation of the O6-methylguanine-DNA methyltransferase (MGMT) gene plays
a role in cellular response to alkylating agents. In the present study aimed to:(i) evaluate the …
a role in cellular response to alkylating agents. In the present study aimed to:(i) evaluate the …
O6‐methylguanine‐DNA methyltransferase activity and sensitivity to cyclophosphamide and cisplatin in human lung tumor xenografts
J Mattern, U Eichhorn, B Kaina… - International journal of …, 1998 - Wiley Online Library
The DNA repair protein O6‐methylguanine‐DNA methyltransferase (MGMT) is a main
determinant of resistance of cells to the cytostatic effects of O6‐alkylguanine‐generating …
determinant of resistance of cells to the cytostatic effects of O6‐alkylguanine‐generating …
MGMT hypermethylation: a prognostic foe, a predictive friend
FV Jacinto, M Esteller - DNA repair, 2007 - Elsevier
Alkylation of DNA at the O6-position of guanine is one of the most critical events leading to
mutation, cancer, and cell death. O6-alkylguanine-DNA alkyltransferase (AGT), also known …
mutation, cancer, and cell death. O6-alkylguanine-DNA alkyltransferase (AGT), also known …