Extent and Patterns of MGMT Promoter Methylation in Glioblastoma- and Respective Glioblastoma-Derived Spheres
D Sciuscio, AC Diserens, K Van Dommelen… - Clinical Cancer …, 2011 - AACR
Purpose: Quantitative methylation-specific tests suggest that not all cells in a glioblastoma
with detectable promoter methylation of the O6-methylguanine DNA methyltransferase …
with detectable promoter methylation of the O6-methylguanine DNA methyltransferase …
MGMT testing—the challenges for biomarker-based glioma treatment
Many patients with malignant gliomas do not respond to alkylating agent chemotherapy.
Alkylator resistance of glioma cells is mainly mediated by the DNA repair enzyme O 6 …
Alkylator resistance of glioma cells is mainly mediated by the DNA repair enzyme O 6 …
O 6 -Methylguanine-DNA Methyltransferase in Pediatric Primary Brain Tumors: Relation to Patient and Tumor Characteristics
MS Bobola, MS Berger, RG Ellenbogen, TS Roberts… - Clinical cancer …, 2001 - AACR
The DNA repair protein O6-methylguanine-DNA methyltransferase (MGMT) confers
resistance to methylating and chloroethylating agents in pediatric medulloblastoma-and …
resistance to methylating and chloroethylating agents in pediatric medulloblastoma-and …
Withholding temozolomide in glioblastoma patients with unmethylated MGMT promoter—still a dilemma?
ME Hegi, R Stupp - Neuro-oncology, 2015 - academic.oup.com
Ten years ago we established O-6-methylguanine-DNA methyltransferase (MGMT) gene
promoter methylation as the first predictive marker in neuro-oncology, and the strongest …
promoter methylation as the first predictive marker in neuro-oncology, and the strongest …
Proteomic analysis of human O6-methylguanine-DNA methyltransferase by affinity chromatography and tandem mass spectrometry
SK Niture, CE Doneanu, CS Velu, NI Bailey… - Biochemical and …, 2005 - Elsevier
Recent evidence suggests that human O6-methylguanine-DNA methyltransferase (MGMT),
a DNA repair protein that protects the genome against mutagens and accords tumor …
a DNA repair protein that protects the genome against mutagens and accords tumor …
In human glioblastomas transcript elongation by alternative polyadenylation and miRNA targeting is a potent mechanism of MGMT silencing
Favorable outcome after chemotherapy of glioblastomas cannot unequivocally be linked to
promoter hypermethylation of the O 6-methylguanine-DNA methyltransferase (MGMT) gene …
promoter hypermethylation of the O 6-methylguanine-DNA methyltransferase (MGMT) gene …
Wnt/β-catenin pathway regulates MGMT gene expression in cancer and inhibition of Wnt signalling prevents chemoresistance
The DNA repair enzyme O6-methylguanine-DNA methyltransferase (MGMT) is commonly
overexpressed in cancers and is implicated in the development of chemoresistance. The …
overexpressed in cancers and is implicated in the development of chemoresistance. The …
O6-Methylguanine-DNA Methyltransferase Expression Strongly Correlates With Outcome in Childhood Malignant Gliomas: Results From the CCG-945 Cohort
IF Pollack, RL Hamilton, RW Sobol… - Journal of clinical …, 2006 - ascopubs.org
Purpose O6-Methylguanine-DNA methyltransferase (MGMT) functions to counteract the
cytotoxic effects of alkylating agents, such as nitrosoureas, which play a central role in the …
cytotoxic effects of alkylating agents, such as nitrosoureas, which play a central role in the …
A novel approach to overcome temozolomide resistance in glioma and melanoma: Inactivation of MGMT by gene therapy
G Jiang, ZP Wei, DS Pei, Y Xin, YQ Liu… - … and Biophysical Research …, 2011 - Elsevier
Malignant glioma is the most common primary brain tumor. Malignant melanoma is the most
malignant of skin tumor. The two malignancies are poorly responsive to conventional …
malignant of skin tumor. The two malignancies are poorly responsive to conventional …
Immunohistochemical study for O6-methylguanine-DNA methyltransferase in the non-neoplastic and neoplastic components of gliomas
S Nakasu, T Fukami, K Baba, M Matsuda - Journal of neuro-oncology, 2004 - Springer
Although the expression O 6-methylguanine-DNA methyltransferase (MGMT) is an important
hallmark for decision of nitrosourea chemotherapy for glioma patients, no …
hallmark for decision of nitrosourea chemotherapy for glioma patients, no …