MGMT promoter methylation correlates with survival benefit and sensitivity to temozolomide in pediatric glioblastoma
AM Donson, SO Addo‐Yobo, MH Handler… - Pediatric blood & …, 2007 - Wiley Online Library
Background Methylation of the DNA‐repair gene O6‐methylguanine‐DNA
methyltransferase (MGMT) causes gene silencing. This epigenetic modification has been …
methyltransferase (MGMT) causes gene silencing. This epigenetic modification has been …
Prognostic value of O6-methylguanine-DNA methyltransferase status in glioblastoma patients, assessed by five different methods
L Karayan-Tapon, V Quillien, J Guilhot, M Wager… - Journal of neuro …, 2010 - Springer
This multicenter study assesses the value of O 6-methylguanine-DNA methyltransferase
(MGMT) status for predicting overall survival in glioblastoma patients. Five methods are …
(MGMT) status for predicting overall survival in glioblastoma patients. Five methods are …
[HTML][HTML] Prognostic Value of Three Different Methods of MGMT Promoter Methylation Analysis in a Prospective Trial on Newly Diagnosed Glioblastoma
A Christians, C Hartmann, A Benner, J Meyer… - PloS one, 2012 - journals.plos.org
Hypermethylation in the promoter region of the MGMT gene encoding the DNA repair
protein O6-methylguanine-DNA methyltransferase is among the most important prognostic …
protein O6-methylguanine-DNA methyltransferase is among the most important prognostic …
Activity of O6‐methylguanine‐DNA methyltransferase in relation to p53 status and therapeutic response in ovarian cancer
JG Hengstler, B Tanner, L Möller… - … journal of cancer, 1999 - Wiley Online Library
The DNA‐repair protein O6‐methylguanine‐DNA methyltransferase (alkyltransferase;
MGMT) is a major determinant of resistance of cells to various alkylating cytostatic drugs. Its …
MGMT) is a major determinant of resistance of cells to various alkylating cytostatic drugs. Its …
Local intracerebral administration of O6-benzylguanine combined with systemic chemotherapy with temozolomide of a patient suffering from a recurrent glioblastoma
D Koch, T Hundsberger, S Boor, B Kaina - Journal of neuro-oncology, 2007 - Springer
The DNA repair protein O 6-methylguanine-DNA methyltransferase (MGMT) is a major
determinant of methylating anticancer drug resistance. Inactivation of MGMT by …
determinant of methylating anticancer drug resistance. Inactivation of MGMT by …
[HTML][HTML] Extent of MGMT promoter methylation correlates with outcome in glioblastomas given temozolomide and radiotherapy
J Dunn, A Baborie, F Alam, K Joyce, M Moxham… - British journal of …, 2009 - nature.com
Background: Epigenetic silencing of O 6-methylguanine-DNA-methyltransferase (MGMT) by
promoter methylation is associated with improved survival in glioblastomas treated with …
promoter methylation is associated with improved survival in glioblastomas treated with …
MGMT Gene Silencing and Benefit from Temozolomide in Glioblastoma
ME Hegi, AC Diserens, T Gorlia… - … England Journal of …, 2005 - Mass Medical Soc
Background Epigenetic silencing of the MGMT (O6-methylguanine–DNA methyltransferase)
DNA-repair gene by promoter methylation compromises DNA repair and has been …
DNA-repair gene by promoter methylation compromises DNA repair and has been …
Intratumoral homogeneity of MGMT promoter hypermethylation as demonstrated in serial stereotactic specimens from anaplastic astrocytomas and glioblastomas
EM Grasbon‐Frodl, FW Kreth, M Ruiter… - … journal of cancer, 2007 - Wiley Online Library
Hypermethylation of the DNA repair gene O6‐methyl‐guanine DNA methyltransferase
(MGMT) has been linked to prolonged survival in glioblastoma patients treated with …
(MGMT) has been linked to prolonged survival in glioblastoma patients treated with …
Combined analysis of O6-methylguanine-DNA methyltransferase protein expression and promoter methylation provides optimized prognostication of glioblastoma …
S Lalezari, AP Chou, A Tran, OE Solis… - Neuro …, 2013 - academic.oup.com
Background Promoter methylation of the DNA repair gene, O-6-methylguanine-DNA
methyltransferase (MGMT), is associated with improved treatment outcome for newly …
methyltransferase (MGMT), is associated with improved treatment outcome for newly …
Human brain tumor O6‐methylguanine‐DNA methyltransferase mRNA and its significance as an indicator of selective chloroethylnitrosourea chemotherapy
K Mineura, T Yanagisawa, K Watanabe… - … journal of cancer, 1996 - Wiley Online Library
Abstract O6‐methylguanine‐DNA methyltransferase (MGMT) removes and repairs
chloroethylnitrosourea (CENU)‐induced O6‐methylguanine‐DNA by accepting the alkyl …
chloroethylnitrosourea (CENU)‐induced O6‐methylguanine‐DNA by accepting the alkyl …