Dosing recommendations for continuous infusion of piperacillin, a broad-spectrum beta-
lactam antibiotic, are mainly guided by outputs from population pharmacokinetic models …

Pharmacokinetic changes are often seen in patients with severe infections. Administration
by continuous infusion has been suggested to optimize antibiotic exposure and …

Objectives Piperacillin is a β-lactam antimicrobial frequently used in critically ill patients with
acute kidney injury treated with continuous renal replacement therapy (CRRT). However …

Abstract Background and Objective Piperacillin is a broad-spectrum β-lactam antibiotic
commonly prescribed in intensive care units. Many piperacillin population pharmacokinetic …

The objectives of this study were (i) to compare the plasma concentration–time profiles for
first-dose and steady-state piperacillin administered by intermittent or continuous dosing to …

Sufficient antibiotic dosing in septic patients is essential for reducing mortality. Piperacillin-
tazobactam is often used for empirical treatment, but due to the pharmacokinetic (PK) …

Piperacillin plasma concentrations are known to vary between critically ill patients. However,
there are no comprehensive data on the variability of antibiotic concentrations within the …

Study Objective To evaluate the pharmacokinetic and pharmacodynamic profiles of
piperacillin‐tazobactam administered as a 4‐hour infusion in critically ill patients undergoing …

This study aimed to characterize the population pharmacokinetics (PKs) of piperacillin and
investigate probability of target attainment (PTA) and cumulative fraction of response (CFR) …

Piperacillin in combination with tazobactam is one of the most commonly used intravenous
antibiotics. There is evidence for a possible saturable elimination of piperacillin. Therefore …