Modulation of host immunity by helminths: the expanding repertoire of parasite effector molecules

RM Maizels, HH Smits, HJ McSorley - Immunity, 2018 - cell.com
Helminths are extraordinarily successful parasites due to their ability to modulate the host
immune response. They have evolved a spectrum of immunomodulatory molecules that are …

[HTML][HTML] Helminth immunoregulation: the role of parasite secreted proteins in modulating host immunity

JP Hewitson, JR Grainger, RM Maizels - Molecular and biochemical …, 2009 - Elsevier
Helminths are masterful immunoregulators. A characteristic feature of helminth infection is a
Th2-dominated immune response, but stimulation of immunoregulatory cell populations …

Helminth parasites–masters of regulation

RM Maizels, A Balic, N Gomez‐Escobar… - Immunological …, 2004 - Wiley Online Library
Immune regulation by parasites is a global concept that includes suppression, diversion,
and conversion of the host immune response to the benefit of the pathogen. While many …

[HTML][HTML] Regulation of the host immune system by helminth parasites

RM Maizels, HJ McSorley - Journal of Allergy and Clinical Immunology, 2016 - Elsevier
Helminth parasite infections are associated with a battery of immunomodulatory
mechanisms that affect all facets of the host immune response to ensure their persistence …

[HTML][HTML] Helminth parasites and immune regulation

PH Gazzinelli-Guimaraes, TB Nutman - F1000Research, 2018 - ncbi.nlm.nih.gov
Helminth parasites are complex metazoans that belong to different taxonomic families but
that collectively share the capacity to downregulate the host immune response directed …

Regulation of pathogenesis and immunity in helminth infections

RM Maizels, EJ Pearce, D Artis… - Journal of Experimental …, 2009 - rupress.org
Helminths are multicellular eukaryotic parasites that infect over one quarter of the world's
population. Through coevolution with the human immune system, these organisms have …

Identifying the immunomodulatory components of helminths

C Shepherd, S Navarro, P Wangchuk… - Parasite …, 2015 - Wiley Online Library
Immunomodulatory components of helminths offer great promise as an entirely new class of
biologics for the treatment of inflammatory diseases. Here, we discuss the emerging themes …

Immunomodulation by helminths: intracellular pathways and extracellular vesicles

A Zakeri, EP Hansen, SD Andersen… - Frontiers in …, 2018 - frontiersin.org
Helminth parasites are masters at manipulating host immune responses, using an array of
sophisticated mechanisms. One of the major mechanisms enabling helminths to establish …

Immunomodulation by helminth parasites: defining mechanisms and mediators

HJ McSorley, JP Hewitson, RM Maizels - International journal for …, 2013 - Elsevier
Epidemiological and interventional human studies, as well as experiments in animal
models, strongly indicate that helminth parasitic infections can confer protection from …

[HTML][HTML] Immune modulation by helminth parasites of ruminants: implications for vaccine development and host immune competence

TN McNeilly, AJ Nisbet - Parasite, 2014 - ncbi.nlm.nih.gov
Parasitic helminths reside in immunologically-exposed extracellular locations within their
hosts, yet they are capable of surviving for extended periods. To enable this survival, these …