1. Adenosine is an endogenous neuromodulator that exerts its depressant effect on neurons
by acting on the A 1 adenosine receptor subtype. Excitatory actions of adenosine, mediated …

Studies done over the last 20 years have clearly shown that the adenosine A 2A receptors
are abundant in the striatum of several animal species. A 2A receptors have also been found …

The distribution, molecular structure and role of adenosine A2 receptors in the nervous
system, is reviewed. The adenosine A2a receptor subtype, identified in the nervous system …

Adenosine acts as a neuromodulator through A1 and A2 receptors. The adenosine analogs
have been recognized, among other effects, as strong depressors of the locomotor activity …

Recent advances in molecular biology, biochemistry, cell biology and behavioral
pharmacology together with the development of more selective ligands to the various …

Adenosine A 2A receptors, which have been cloned from several mammalian species, are
activated by physiological concentrations of adenosine to stimulate the formation of cAMP …

There is growing evidence that adenosine is a potent inhibitor of neuronal activity in the
central (CNS) and peripheral nervous systems. Four major subtypes of adenosine receptors …

Adenosine A1 receptors are known to be widely distributed in variousregionsof the brain.
A@ receptorsare enrichedin the dopamine-nch areas of the brain, but are also present in rat …

The expression of the human adenosine A2A receptor was examined by reverse
transcription polymerase chain reaction in post-mortem human brain tissue that was …

Adenosine plays a key role in the regulation of tissue oxygenation, neuronal firing, and
neurotransmitter release. Four receptor subtypes have been identified and cloned: A 1, A …