A cDNA encoding a G protein-coupled receptor of unknown ligand specificity was isolated
from a human hippocampal cDNA library by virtue of the high degree of structural homology …

The A 2 selective adenosine receptor agonist 2-p-(2-car☐ yethyl) phenethylamino-5′-N-
ethylcar☐ amidoadenosine (CGS 21680) depressed the spontaneous, acetylcholine-and …

Characterization of the adenosine A2 receptor has been limited due to the lack of available
ligands which have high affinity and selectivity for this adenosine receptor subtype. In the …

Since high-affinity adenosine A2 receptors (A2a) are localized exclusively in dopamine-rich
regions in the central nervous system and mediate inhibition of locomotor activity, we have …

* Address correspondence to: PJM van Galen, NIH/NIDDK, Building 8A, Room B1A-17,
Bethesda, MD 20892; telephone 301-496-9024; fax 301-402-0008. Medicinal Research …

Previous work has been carried out on the effects of adenosine on transmitter release and
on the excitability of postsynaptic neurones, but little is known about the effects of adenosine …

Adenosine participates in the physiology of central and peripheral tissues through several
subtypes of G-protein-coupled receptors. Positively linked to adenylate cyclase, A2 …

Adenosine A1 and A2 receptors have been the subject of intense activity in the
pharmaceutical industry. Adenosine agonists, which are almost exclusively derivatives of …

Adenosine's diverse physiological functions are mediated by four subtypes of receptors (A1,
A2A, A2B and A3). The A1 adenosine receptor pharmacology and therapeutic application of …

2‐p‐(2‐carboxyethylphenethylamino‐5′‐ethylcarboxamidoadenosine)(CGS 21680) is
considered the reference compound to study adenosine A2A receptors. However, CGS …