Binding of the prototypical adenosine A2A receptor agonist CGS 21680 to the cerebral cortex of adenosine A1 and A2A receptor knockout mice
2‐p‐(2‐carboxyethylphenethylamino‐5′‐ethylcarboxamidoadenosine)(CGS 21680) is
considered the reference compound to study adenosine A2A receptors. However, CGS …
considered the reference compound to study adenosine A2A receptors. However, CGS …
Adenosine in the central nervous system: effects on neurotransmission and neuroprotection
F Pedata, AM Pugliese, E Coppi… - … & Metabolic Agents …, 2007 - ingentaconnect.com
Adenosine is one of the principal neuromodulators in the brain and acts on four specific
receptor subtypes: the A1, A2A, A2B and A3 receptors. Adenosine concentrations normally …
receptor subtypes: the A1, A2A, A2B and A3 receptors. Adenosine concentrations normally …
Cloning and expression of a bovine adenosine A1 receptor cDNA
AL Tucker, J Linden, AS Robeva, DD D'Angelo… - FEBS …, 1992 - Wiley Online Library
A bovine brain adenosine A1 receptor cDNA encoding a 326 amino acid protein has been
identified. This cDNA, which encodes a protein> 90% identical to analogous rat and dog …
identified. This cDNA, which encodes a protein> 90% identical to analogous rat and dog …
In vivo labelling of the adenosine A2A receptor in mouse brain using the selective antagonist [3H]SCH 58261
M El Yacoubi, C Ledent, M Parmentier… - European Journal of …, 2001 - Wiley Online Library
The selective A2A receptor antagonist [3H] SCH 58261 was injected intravenously in mice
and the radioactivity accumulating in various brain regions was determined by tissue …
and the radioactivity accumulating in various brain regions was determined by tissue …
Characterization of two affinity states of adenosine A2a receptors with a new radioligand, 2-[2-(4-amino-3-[125I] iodophenyl) ethylamino] adenosine.
DR Luthin, RA Olsson, RD Thompson… - Molecular …, 1995 - ASPET
Adenosine analogs substituted in the 2-position with arylamino groups have been found to
have high affinity and selectivity for A2a adenosine receptors. Two such compounds, 2-[2-(4 …
have high affinity and selectivity for A2a adenosine receptors. Two such compounds, 2-[2-(4 …
Immunological identification of A1 adenosine receptors in brain cortex
The A1 adenosine receptor from pig brain cortex has been identified by means of two
antipeptide antibodies against two domains of the receptor molecule: PC/10 antiserum was …
antipeptide antibodies against two domains of the receptor molecule: PC/10 antiserum was …
A1 receptors self-regulate adenosine release in the striatum: evidence of autoreceptor characteristics
S Cechova, AM Elsobky, BJ Venton - Neuroscience, 2010 - Elsevier
Adenosine A1 receptors are inhibitory G-protein coupled receptors that presynaptically
regulate neurotransmitter release, but their role in self-regulating adenosine release is not …
regulate neurotransmitter release, but their role in self-regulating adenosine release is not …
Electrophysiological responses to adenosine analogs in rat hippocampus and cerebellum: evidence for mediation by adenosine receptors of the A1 subtype
TV Dunwiddie, AS Basile, MR Palmer - Life sciences, 1984 - Elsevier
Adenosine has profound depressant effects upon the electrophysiological activity of the
brain, but the adenosine receptor subtypes which mediate these responses are uncertain. In …
brain, but the adenosine receptor subtypes which mediate these responses are uncertain. In …
Ultrastructural localization of adenosine A2A receptors suggests multiple cellular sites for modulation of GABAergic neurons in rat striatum
Activation of adenosine A2A receptors (A2AR) has been shown to antagonize the function of
D2 dopaminergic regulation of striatal γ‐aminobutyric acid (GABA)‐ergic output and, thus …
D2 dopaminergic regulation of striatal γ‐aminobutyric acid (GABA)‐ergic output and, thus …
Adenosine A3 receptors are located in neurons of the rat hippocampus
Adenosine is a neuromodulator acting mainly via inhibitory A 1 and facilitatory A 2A
receptors. Whole tissue PCR also identified adenosine A 3 receptors in the brain and A 3 …
receptors. Whole tissue PCR also identified adenosine A 3 receptors in the brain and A 3 …