The microbial basis of impaired wound healing: differential roles for pathogens,“bystanders”, and strain-level diversification in clinical outcomes

L Kalan, JS Meisel, MA Loesche, J Horwinski, I Soaita… - bioRxiv, 2018 - biorxiv.org
Chronic, non-healing wounds are a major complication of diabetes associated with high
morbidity and health care expenditures estimated at $9-13 billion annually in the US …

Strain-and species-level variation in the microbiome of diabetic wounds is associated with clinical outcomes and therapeutic efficacy

LR Kalan, JS Meisel, MA Loesche, J Horwinski… - Cell host & …, 2019 - cell.com
Chronic wounds are a major complication of diabetes associated with high morbidity and
health care expenditures. To investigate the role of colonizing microbiota in diabetic wound …

Redefining the chronic-wound microbiome: fungal communities are prevalent, dynamic, and associated with delayed healing

L Kalan, M Loesche, BP Hodkinson, K Heilmann… - MBio, 2016 - Am Soc Microbiol
Chronic nonhealing wounds have been heralded as a silent epidemic, causing significant
morbidity and mortality especially in elderly, diabetic, and obese populations. Polymicrobial …

The dynamic wound microbiome

C Liu, AJ Ponsero, DG Armstrong, BA Lipsky… - BMC medicine, 2020 - Springer
Abstract Background Diabetic foot ulcers (DFUs) account for the majority of all limb
amputations and hospitalizations due to diabetes complications. With 30 million cases of …

The wound microbiome

A Uberoi, A Campbell, EA Grice - Wound Healing, Tissue Repair, and …, 2020 - Elsevier
The wound microbiome consists of living microbial communities (“microbiota”) that interact
with each other and their surroundings in the injured tissue. The role of the wound …

[HTML][HTML] Microbiota of chronic diabetic wounds: ecology, impact, and potential for innovative treatment strategies

SG Pereira, J Moura, E Carvalho… - Frontiers in …, 2017 - frontiersin.org
World Health Organization considered diabetes as one of the 20th century epidemics,
estimating that over 10% of the world population is diabetic or at high risk. Self-assessment …

Examining diabetic heel ulcers through an ecological lens: microbial community dynamics associated with healing and infection

TJ Sloan, JC Turton, J Tyson… - Journal of medical …, 2019 - microbiologyresearch.org
Purpose. While some micro-organisms, such as Staphylococcus aureus, are clearly
implicated in causing tissue damage in diabetic foot ulcers (DFUs), our knowledge of the …

The neuropathic diabetic foot ulcer microbiome is associated with clinical factors

SE Gardner, SL Hillis, K Heilmann, JA Segre… - Diabetes, 2013 - Am Diabetes Assoc
Nonhealing diabetic foot ulcers (DFUs) are a common and costly complication of diabetes.
Microbial burden, or “bioburden,” is believed to underlie delayed healing, although little is …

The role of the microbiome in nonhealing diabetic wounds

LR Kalan, MB Brennan - Annals of the New York Academy of …, 2019 - Wiley Online Library
Wound healing is a highly coordinated and complex process, and there can be devastating
consequences if it is interrupted. It is believed that, in combination with host factors …

Bad “staph” in the wound environment of diabetic foot ulcers

AS MacLeod - Cell Host & Microbe, 2019 - cell.com
Diabetic foot ulcers (DFUs) are a leading cause of high morbidity among diabetic patients. In
this issue of Cell Host & Microbe, Kalan et al.(2019) examine the microbial bio-burden of …