Background DNA replication in trypanosomatids operates in a uniquely challenging
environment, since most of their genomes are constitutively transcribed. Trypanosoma cruzi …

Trypanosoma cruzi is the etiologic agent of the most prevalent human parasitic disease in
Latin America, Chagas disease. Its genome is rich in multigenic families that code for …

Background Trypanosoma cruzi, the etiologic agent of Chagas disease, is currently divided
into six discrete typing units (DTUs), named TcI–TcVI. CL Brener, the reference strain of the …

Identification of replication initiation sites, termed origins, is a crucial step in understanding
genome transmission in any organism. Transcription of the Trypanosoma brucei genome is …

Here, we investigated the features of replication in Trypanosoma cruzi epimastigotes based
on fork speed progression, which is influenced by distinct features such as DNA polymerase …

Eukaryotic genome duplication relies on origins of replication, distributed over multiple
chromosomes, to initiate DNA replication. A recent genome-wide analysis of Trypanosoma …

In eukaryotes, many nuclear processes are spatially compartmentalized. Previously, we
have shown that in Trypanosoma cruzi, an early-divergent eukaryote, DNA replication …

Survival of Trypanosoma brucei depends upon switches in its protective Variant Surface
Glycoprotein (VSG) coat by antigenic variation. VSG switching occurs by frequent …

Protozoa and fungi are known to have extraordinarily diverse mechanisms of genetic
exchange. However, the presence and epidemiological relevance of genetic exchange in …

Background Trypanosoma cruzi is a protozoan parasite and the etiologic agent of Chagas
disease, an important public health problem in Latin America. T. cruzi is diploid, almost …