Status of glutathione during oxidant-induced oxidative stress in the preimplantation mouse embryo

CS Gardiner, DJ Reed - Biology of reproduction, 1994 - academic.oup.com
Experiments were conducted to elucidate the status of glutathione present in the oxidized
(GSSG), reduced (GSH), and protein-mixed disulfide (GSSprotein) forms in preimplantation …

Glutathione redox cycle-driven recovery of reduced glutathione after oxidation by tertiary-butyl hydroperoxide in preimplantation mouse embryos

CS Gardiner, DJ Reed - Archives of biochemistry and biophysics, 1995 - Elsevier
The purpose of this study was to determine whether mouse embryos at the two-cell to
blastocyst stage have the capacity to reduce glutathione disulfide (GSSG) and to elucidate …

Quantitative analysis of cellular glutathione in early preimplantation mouse embryos developing in vivo and in vitro

MH Nasr-Esfahani, MH Johnson - Human Reproduction, 1992 - academic.oup.com
The relative levels of reduced glutathione (GSH) have been measured fluorimetrically in
individual eggs and early embryos from two mouse strains, one of which shows …

Synthesis of glutathione in the preimplantation mouse embryo

CS Gardiner, DJ Reed - Archives of biochemistry and biophysics, 1995 - Elsevier
Depletion and repletion of glutathione in two-cell to blastocyst stage mouse embryos was
examined, Reduced (GSH) and oxidized glutathione (GSSG) were measured by fluorimetric …

Glutathione is present in reproductive tract secretions and improves development of mouse embryos after chemically induced glutathione depletion

CS Gardiner, JJ Salmen, CJ Brandt… - Biology of …, 1998 - academic.oup.com
We investigated the hypothesis that reduced glutathione (GSH) is present in secretions of
the female reproductive tract and that this extracellular GSH may protect preimplantation …

Oxygen-induced embryopathy and the significance of glutathione-dependent antioxidant system in the rat embryo during early organogenesis

M Ishibashi, S Akazawa, H Sakamaki… - Free Radical Biology …, 1997 - Elsevier
We investigated the effect of glutathione (GSH)-dependent antioxidant system against
hydrogen peroxide (H2O2) formation in oxygen-induced embryopathy. Exposure of rat …

Antioxidants improve mouse preimplantation embryo development and viability

TT Truong, YM Soh, DK Gardner - Human Reproduction, 2016 - academic.oup.com
STUDY QUESTION What is the effect of three antioxidants (acetyl-L-carnitine, N-acetyl-L-
cysteine and α-lipoic acid), when used individually and in combination, on mouse embryo …

Preimplantation embryotoxicity after mouse embryo exposition to reactive oxygen species

E Cebral, I Carrasco, D Vantman, R Smith - Biocell, 2007 - SciELO Argentina
Exposure of either gametes or embryos to conditions and/or factors that generate oxidative
stress has been associated with impaired early embryogenesis. The effects of reactive …

Protection against reactive oxygen species during mouse preimplantation embryo development: role of EDTA, oxygen tension, catalase, superoxide dismutase and …

NM Orsi, HJ Leese - Molecular Reproduction and …, 2001 - Wiley Online Library
Oxidative damage due to the production of reactive oxygen species (ROS) is one of a
number of culture‐induced stresses which may compromise preimplantation embryo …

Oxidative stress and redox regulation on in vitro development of mammalian embryos

M Takahashi - Journal of Reproduction and Development, 2012 - jstage.jst.go.jp
Many factors affect development of mammalian preimplantation embryos in vitro. It is well
known that in vitro development of bovine embryos is highly affected by culture condition …