The inflammatory bowel diseases (IBDs), Crohn's disease and ulcerative colitis, are chronic
inflammatory disorders of the gastrointestinal tract. Enormous progress has been made …

The innate immune system is a key factor in understanding the pathogenesis of
inflammatory bowel disease (IBD) and in the hopes of improving its treatment. NOD2, a …

Research in the pathogenesis of inflammatory bowel disease (IBD) has dramatically
broadened our understanding of these complex disorders. These clinical manifestations …

Considerable progress has been made in the last decade in studies of the genetics of the
inflammatory bowel diseases, Crohn's disease and ulcerative colitis. Epidemiological data …

Genome-wide association studies efficiently and powerfully assay common genetic
variation. The application of these studies to Crohn's disease has provided insight into the …

The inflammatory bowel diseases (IBD) are comprised of two major subphenotypes, Crohn's
disease (CD) and ulcerative colitis (UC). A significant role for genetic factors in IBD was …

Mutations of the NOD2 gene have been associated with an increased susceptibility to
Crohn's disease, but the pathogenetic mechanisms mediated by NOD2 remain elusive. In …

NOD2, a gene conferring susceptibility to Crohn's disease, has been identified on
chromosome 16. Homozygosity for a mutation that truncates the gene increases the risk of …

Inflammatory bowel diseases (IBDs) are complex, multifactorial disorders that comprise
Crohn's disease (CD) and ulcerative colitis (UC). Genome-wide association studies have …

The discovery of nucleotide-binding oligomerization domain 2/caspase recruitment domain-
containing protein 15 (NOD2/CARD15) as the first susceptibility gene in Crohn's disease …