Fetal, maternal, and placental sources of serotonin and new implications for developmental programming of the brain

A Bonnin, P Levitt - Neuroscience, 2011 - Elsevier
In addition to its role in neurotransmission, embryonic serotonin (5-HT) has been implicated
in the regulation of neurodevelopmental processes. For example, we recently showed that a …

Postnatal changes in serotonin1 receptors following prenatal alterations in serotonin levels: further evidence for functional fetal serotonin1 receptors

PM Whitaker-Azmitia, JM Lauder, A Shemmer… - Developmental Brain …, 1987 - Elsevier
Recent work by ourselves and others has indicated that serotonin (5-HT) acts as a regulator
of neuronal growth in fetal tissue, probably through an action on the high affinity 5-HT …

A transient placental source of serotonin for the fetal forebrain

A Bonnin, N Goeden, K Chen, ML Wilson, J King… - Nature, 2011 - nature.com
Abstract Serotonin (5-hydroxytryptamine or 5-HT) is thought to regulate neurodevelopmental
processes through maternal–fetal interactions that have long-term mental health …

Maternal serotonin is crucial for murine embryonic development

F Côté, C Fligny, E Bayard… - Proceedings of the …, 2007 - National Acad Sciences
The early appearance of serotonin and its receptors during prenatal development, together
with the many effects serotonin exerts during CNS morphogenesis, strongly suggest that …

[HTML][HTML] Placental serotonin: implications for the developmental effects of SSRIs and maternal depression

JC Velasquez, N Goeden, A Bonnin - Frontiers in cellular …, 2013 - frontiersin.org
In addition to its role in the pathophysiology of numerous psychiatric disorders, increasing
evidence points to serotonin (5-HT) as a crucial molecule for the modulation of …

Gestational factors throughout fetal neurodevelopment: the serotonin link

SI Hanswijk, M Spoelder, L Shan, MMM Verheij… - International journal of …, 2020 - mdpi.com
Serotonin (5-HT) is a critical player in brain development and neuropsychiatric disorders.
Fetal 5-HT levels can be influenced by several gestational factors, such as maternal …

Expression mapping of 5-HT1 serotonin receptor subtypes during fetal and early postnatal mouse forebrain development

A Bonnin, W Peng, W Hewlett, P Levitt - Neuroscience, 2006 - Elsevier
Serotonin (5-HT) is implicated in several aspects of brain development, yet the ontogenetic
expression patterns of 5-HT receptors responsible for transducing specific effects have …

[HTML][HTML] Refining the role of 5-HT in postnatal development of brain circuits

A Teissier, M Soiza-Reilly, P Gaspar - Frontiers in cellular …, 2017 - frontiersin.org
Changing serotonin (5-hydroxytryptamine, 5-HT) brain levels during critical periods in
development has long-lasting effects on brain function, particularly on later …

Maternal inflammation disrupts fetal neurodevelopment via increased placental output of serotonin to the fetal brain

N Goeden, J Velasquez, KA Arnold… - Journal of …, 2016 - Soc Neuroscience
Maternal inflammation during pregnancy affects placental function and is associated with
increased risk of neurodevelopmental disorders in the offspring. The molecular mechanisms …

Expression of serotonin transporter protein in developing rat brain

FC Zhou, Y Sari, JK Zhang - Developmental Brain Research, 2000 - Elsevier
Serotonin transporter (5-HTT), a transmembrane protein, has been shown in adult brain to
be distributed not only on synaptic terminals but to a great extent on axons as well. Here we …