Context: Amiodarone (an iodinated benzofuran) is a Class III antiarrhythmic drug that
produces significant pulmonary disease. Proposed mechanisms of this cytotoxicity include …

Amiodarone (AM), a potent antidysrhythmic agent, can cause potentially life-threatening
pulmonary fibrosis. In the present investigation of mechanisms of initiation of AM lung …

Amiodarone (AM) is an efficacious antidysrhythmic agent that is limited clinically by
numerous adverse effects. Of greatest concern is AM-induced pulmonary toxicity (AIPT) due …

Amiodarone (AM), a drug used in the treatment of cardiac dysrrhythmias, can produce
severe pulmonary adverse effects, including fibrosis. Although the pathogenesis of AM …

Conclusions Since the discovery of amiodarone over 30 years ago, the mechanisms
underlying serious adverse effects remain to be resolved and still limit drug usefulness …

Associated with amiodarone (AM) therapy is pneumonitis, which may progress to life-
threatening pulmonary fibrosis. Although the etiology of amiodarone-induced pulmonary …

Amiodarone-induced pulmonary toxicity is a serious side-effect, but the underlying
molecular mechanisms remain unclear. We examined phospholipidosis and apoptosis in rat …

Amiodarone (AM) is a potent antidysrhythmic agent which can cause potentially
lifethreatening pulmonary fibrosis, and N-desethylamiodarone (DEA) is a metabolite of AM …

Amiodarone (AM) is an effective antidysrhythmic agent, restricted in use by the development
of adverse effects, including potentially fatal AM‐induced pulmonary toxicity (AIPT). Although …

Amiodarone‐(AM‐) induced pulmonary toxicity (AIPT) is still a matter of research and is
poorly understood. In attempting to resolve this issue, we treated Sprague‐Dawley rats with …