PGC-1α overexpression is not sufficient to mitigate cancer cachexia in either male or female mice

F Morena da Silva, ME Rosa-Caldwell… - Applied Physiology …, 2022 - cdnsciencepub.com
Cancer cachexia (CC) accounts for 20%–40% of cancer-related deaths. Mitochondrial
aberrations have been shown to precede muscle atrophy in different atrophy models …

[HTML][HTML] Increase in muscle mitochondrial biogenesis does not prevent muscle loss but increased tumor size in a mouse model of acute cancer-induced cachexia

X Wang, AM Pickrell, TA Zimmers, CT Moraes - PloS one, 2012 - journals.plos.org
Cancer-associated cachexia is a complex metabolic condition characterized by the
progressive loss of body fat and deterioration of muscle mass. Although the cellular and …

[HTML][HTML] Mitochondrial dysfunction in cancer cachexia: impact on muscle health and regeneration

M Beltrà, F Pin, R Ballarò, P Costelli, F Penna - Cells, 2021 - mdpi.com
Cancer cachexia is a frequently neglected debilitating syndrome that, beyond representing a
primary cause of death and cancer therapy failure, negatively impacts on patients' quality of …

Mitochondrial degeneration precedes the development of muscle atrophy in progression of cancer cachexia in tumour‐bearing mice

JL Brown, ME Rosa‐Caldwell, DE Lee… - Journal of cachexia …, 2017 - Wiley Online Library
Background Cancer cachexia is largely irreversible, at least via nutritional means, and
responsible for 20–40% of cancer‐related deaths. Therefore, preventive measures are of …

PGC1α overexpression preserves muscle mass and function in cisplatin‐induced cachexia

JR Huot, F Pin, R Chatterjee… - Journal of Cachexia …, 2022 - Wiley Online Library
Background Chemotherapy induces a cachectic‐like phenotype, accompanied by skeletal
muscle wasting, weakness and mitochondrial dysfunction. Peroxisome proliferator‐activated …

Nuclear magnetic resonance in conjunction with functional genomics suggests mitochondrial dysfunction in a murine model of cancer cachexia

C Constantinou… - International …, 2011 - spandidos-publications.com
Cancer patients commonly suffer from cachexia, a syndrome in which tumors induce
metabolic changes in the host that lead to massive loss in skeletal muscle mass. Using a …

Obesity worsens mitochondrial quality control and does not protect against skeletal muscle wasting in murine cancer cachexia

TD Cardaci, BN VanderVeen… - Journal of Cachexia …, 2024 - Wiley Online Library
Background More than 650 million people are obese (BMI> 30) worldwide, which increases
their risk for several metabolic diseases and cancer. While cachexia and obesity are at …

Autophagy exacerbates muscle wasting in cancer cachexia and impairs mitochondrial function

F Penna, R Ballarò, P Martinez-Cristobal, D Sala… - Journal of molecular …, 2019 - Elsevier
Cancer cachexia is a multifactorial syndrome characterized by anorexia, weight loss and
muscle wasting that impairs patients' quality of life and survival. Aim of this work was to …

Transcriptomic analysis of the development of skeletal muscle atrophy in cancer-cachexia in tumor-bearing mice

TA Blackwell, I Cervenka, B Khatri… - Physiological …, 2018 - journals.physiology.org
Cancer-cachexia (CC) is a wasting condition directly responsible for 20–40% of cancer-
related deaths. The mechanisms controlling development of CC-induced muscle wasting …

[HTML][HTML] Baoyuan Jiedu decoction alleviates cancer-induced myotube atrophy by regulating mitochondrial dynamics through p38 MAPK/PGC-1α signaling pathway

D Wang, W Chen, Q Bi, X Zong, J Ruan, X Yin… - Frontiers in …, 2020 - frontiersin.org
Cancer cachexia is a multifactorial syndrome characterized by continuous body wasting and
loss of skeletal muscle. Impaired mitochondria function is closely associated with muscle …