In 1969 Li and Fraumeni identified, from a systematic study of 648 children with
rhabdomyosarcomas, five families in which a sibling or a cousin was affected by sarcoma (Li …

Abstract The Li-Fraumeni cancer family syndrome is manifested by susceptibility to breast
cancer, sarcomas, and other neoplasms in children and young adults. The present study …

The goal of this review is to demonstrate the effective interaction of epidemiologic methods
and molecular genetics in the identification of familial cancer predisposition. The example …

Li-Fraumeni syndrome (LFS) is a cancer predisposition syndrome associated with high risks
for a broad spectrum of cancers including early-onset cancers. Five cancer types account for …

The cancer experience among 754 first‐degree relatives (mothers, fathers, and siblings) of a
population‐based series of 177 children with soft tissue sarcoma is reported. the current …

Li–Fraumeni syndrome (LFS) has been the most common terminology used for the
syndrome. It is a rare familial dominantly inherited cancer syndrome characterized by a wide …

A database has been created to collect information on families carrying a germ-line mutation
in the TP53 gene and on families affected with Li-Fraumeni syndromes [Li-Fraumeni …

Abstract Background: Li-Fraumeni syndrome is a dominantly inherited disorder
characterized by early-onset breast cancer, sarcomas, and other cancers in children and …

Abstract The Li-Fraumeni familial cancer syndrome was initially described in 1969 in a
retrospective epidemiologic review of more than 600 pediatric sarcoma patients. The clinical …

Purpose The aim of the study was to update the description of Li-Fraumeni syndrome (LFS),
a remarkable cancer predisposition characterized by extensive clinical heterogeneity …