[HTML][HTML] c-Jun N-terminal kinase 2 promotes enterocyte survival and goblet cell differentiation in the inflamed intestine
Abstract c-Jun N-terminal kinases (JNKs) contribute to immune signaling but their functional
role during intestinal mucosal inflammation has remained ill defined. Using genetic mouse …
role during intestinal mucosal inflammation has remained ill defined. Using genetic mouse …
c-Jun NH2-terminal kinase 1 plays a critical role in intestinal homeostasis and tumor suppression
C Tong, Z Yin, Z Song, A Dockendorff, C Huang… - The American journal of …, 2007 - Elsevier
The c-Jun NH2-terminal kinase (JNK) signal transduction pathway plays important roles in
cellular processes and stress. However, the role of JNK1 in intestinal homeostasis and …
cellular processes and stress. However, the role of JNK1 in intestinal homeostasis and …
[HTML][HTML] Intestinal epithelial cell endoplasmic reticulum stress promotes MULT1 up-regulation and NKG2D-mediated inflammation
S Hosomi, J Grootjans… - The Journal of …, 2017 - ncbi.nlm.nih.gov
Endoplasmic reticulum (ER) stress is commonly observed in intestinal epithelial cells (IECs)
and can, if excessive, cause spontaneous intestinal inflammation as shown by mice with IEC …
and can, if excessive, cause spontaneous intestinal inflammation as shown by mice with IEC …
The impact of JNK inhibitor D-JNKI-1 in a murine model of chronic colitis induced by dextran sulfate sodium
S Kersting, V Behrendt, J Kersting… - Journal of …, 2013 - Taylor & Francis
Purpose The c-Jun N-terminal kinases (JNK) are involved in the activation of T cells and the
synthesis of proinflammatory cytokines. Several studies have established the relevance of …
synthesis of proinflammatory cytokines. Several studies have established the relevance of …
Differential requirement for c-Jun N-terminal kinase 1 in lung inflammation and host defense
J Van der Velden, YMW Janssen-Heininger… - PloS one, 2012 - journals.plos.org
The c-Jun N-terminal kinase (JNK)-1 pathway has been implicated in the cellular response
to stress in many tissues and models. JNK1 is known to play a role in a variety of signaling …
to stress in many tissues and models. JNK1 is known to play a role in a variety of signaling …
Blockade of NKG2D signaling prevents the development of murine CD4+ T cell-mediated colitis
Y Ito, T Kanai, T Totsuka, R Okamoto… - American Journal …, 2008 - journals.physiology.org
It has been recently demonstrated that NKG2D is an activating costimulatory receptor on
natural killer (NK) cells, natural killer T (NKT) cells, activated CD8+ T cells, and γδ T cells …
natural killer (NK) cells, natural killer T (NKT) cells, activated CD8+ T cells, and γδ T cells …
c-Jun NH2-terminal kinase-2 mediates osmotic stress-induced tight junction disruption in the intestinal epithelium
G Samak, T Suzuki, A Bhargava… - American Journal of …, 2010 - journals.physiology.org
Gastrointestinal epithelium faces osmotic stress, both at physiological and
pathophysiological conditions. JNK activation is an immediate cellular response to osmotic …
pathophysiological conditions. JNK activation is an immediate cellular response to osmotic …
Genetic deletion of JNK1 and JNK2 aggravates the DSS-induced colitis in mice
AM Chromik, AM Müller, J Körner… - Journal of …, 2007 - Taylor & Francis
The c-Jun N-terminal kinases (JNKs) are considered as novel targets for therapy of
inflammatory bowel diseases (IBD). However, the relevant JNK isoforms have to be …
inflammatory bowel diseases (IBD). However, the relevant JNK isoforms have to be …
[HTML][HTML] Protein kinase CK2 is a critical regulator of epithelial homeostasis in chronic intestinal inflammation
S Koch, CT Capaldo, RS Hilgarth, B Fournier… - Mucosal …, 2013 - Elsevier
The molecular mechanisms that restore intestinal epithelial homeostasis during colitis are
incompletely understood. Here, we report that during intestinal inflammation, multiple …
incompletely understood. Here, we report that during intestinal inflammation, multiple …
Knockout of the c-Jun N-terminal Kinase 2 aggravates the development of mild chronic dextran sulfate sodium colitis independently of expression of intestinal …
S Kersting, K Reinecke, C Hilgert… - Journal of …, 2013 - Taylor & Francis
Introduction The c-Jun N-terminal kinases (JNKs) are involved in signal transduction of
inflammatory bowel diseases. The aim of this study was to examine the function of JNKs by …
inflammatory bowel diseases. The aim of this study was to examine the function of JNKs by …