Abstract c-Jun N-terminal kinases (JNKs) contribute to immune signaling but their functional
role during intestinal mucosal inflammation has remained ill defined. Using genetic mouse …

The c-Jun NH2-terminal kinase (JNK) signal transduction pathway plays important roles in
cellular processes and stress. However, the role of JNK1 in intestinal homeostasis and …

Endoplasmic reticulum (ER) stress is commonly observed in intestinal epithelial cells (IECs)
and can, if excessive, cause spontaneous intestinal inflammation as shown by mice with IEC …

Purpose The c-Jun N-terminal kinases (JNK) are involved in the activation of T cells and the
synthesis of proinflammatory cytokines. Several studies have established the relevance of …

The c-Jun N-terminal kinase (JNK)-1 pathway has been implicated in the cellular response
to stress in many tissues and models. JNK1 is known to play a role in a variety of signaling …

It has been recently demonstrated that NKG2D is an activating costimulatory receptor on
natural killer (NK) cells, natural killer T (NKT) cells, activated CD8+ T cells, and γδ T cells …

Gastrointestinal epithelium faces osmotic stress, both at physiological and
pathophysiological conditions. JNK activation is an immediate cellular response to osmotic …

The c-Jun N-terminal kinases (JNKs) are considered as novel targets for therapy of
inflammatory bowel diseases (IBD). However, the relevant JNK isoforms have to be …

The molecular mechanisms that restore intestinal epithelial homeostasis during colitis are
incompletely understood. Here, we report that during intestinal inflammation, multiple …

Introduction The c-Jun N-terminal kinases (JNKs) are involved in signal transduction of
inflammatory bowel diseases. The aim of this study was to examine the function of JNKs by …