Role of Catabolite Control Protein A in the Regulation of Intermedilysin Production by Streptococcus intermedius

T Tomoyasu, A Tabata, R Hiroshima, H Imaki… - Infection and …, 2010 - Am Soc Microbiol
Streptococcus intermedius is an opportunistic pathogen of humans that causes purulent
infections, including brain and liver abscesses. This pathogen secretes a human-specific …

Positive-and negative-control pathways by blood components for intermedilysin production in Streptococcus intermedius

T Tomoyasu, T Yamasaki, S Chiba, S Kusaka… - Infection and …, 2017 - Am Soc Microbiol
Streptococcus intermedius is an opportunistic bacterial pathogen secreting a human-specific
cytolysin called intermedilysin (ILY) as a major pathogenic factor. This bacterium can …

LacR mutations are frequently observed in Streptococcus intermedius and are responsible for increased intermedilysin production and virulence

T Tomoyasu, H Imaki, S Masuda, A Okamoto… - Infection and …, 2013 - Am Soc Microbiol
Streptococcus intermedius secretes a human-specific cytolysin, intermedilysin (ILY), which is
considered to be the major virulence factor of this pathogen. We screened for a repressor of …

Distribution of the intermedilysin gene among the anginosus group streptococci and correlation between intermedilysin production and deep-seated infection with …

H Nagamune, RA Whiley, T Goto, Y Inai… - Journal of clinical …, 2000 - Am Soc Microbiol
The distribution of intermedilysin, a human-specific cytolysin, among the anginosus group
streptococci and the correlation of toxin production and infection by Streptococcus …

Intermedilysin Is Essential for the Invasion of Hepatoma HepG2 Cells by Streptococcus intermedius

A Sukeno, H Nagamune, RA Whiley… - Microbiology and …, 2005 - Wiley Online Library
Streptococcus intermedius causes endogenous infections leading to abscesses. This
species produces intermedilysin (ILY), a human‐specific cytolysin. Because of the significant …

Effect on Polymorphonuclear Cell Function of a Human-Specific Cytotoxin, Intermedilysin, Expressed byStreptococcus intermedius

MG Macey, RA Whiley, L Miller… - Infection and …, 2001 - Am Soc Microbiol
Streptococcus intermedius is a member of the normal flora of the mouth but is also an
opportunistic pathogen associated with purulent infections at oral and nonoral sites …

Characterization of DNA binding sites of the ComE response regulator from Streptococcus mutans

DCI Hung, JS Downey, EA Ayala, J Kreth… - Journal of …, 2011 - Am Soc Microbiol
In Streptococcus mutans, both competence and bacteriocin production are controlled by
ComC and the ComED two-component signal transduction system. Recent studies of S …

[HTML][HTML] Identification of the high affinity binding site in the Streptococcus intermedius toxin intermedilysin for its membrane receptor, the human complement regulator …

TR Hughes, KS Ross, GJM Cowan, B Sivasankar… - Molecular …, 2009 - Elsevier
The unique species specificity of the bacterial cytolysin intermedilysin is explained by its
requirement for the human complement regulator CD59 as the primary receptor. Binding …

Catabolite control protein a of Streptococcus suis type 2 contributes to sugar metabolism and virulence

Y Tang, W Wu, X Zhang, Z Lu, J Chen, W Fang - Journal of Microbiology, 2012 - Springer
Catabolite control protein A (CcpA) is the major transcriptional regulator in carbon catabolite
repression in several Gram-positive bacteria. We attempted to characterize the role of a …

Regulation of cid and lrg expression by CcpA in Streptococcus mutans

HM Kim, A Waters, ME Turner, KC Rice… - …, 2019 - microbiologyresearch.org
The Streptococcus mutans Cid/Lrg system represents an ideal model for studying this
organism's ability to withstand various stressors encountered in the oral cavity. The lrg and …