In Streptococcus mutans, competence for genetic transformation and biofilm formation are
dependent on the two-component signal transduction system ComDE together with the …

The ability of a pathogen to metabolically adapt to the local environment for optimal
expression of virulence determinants is a continued area of research. Orthologs of the …

The production of streptocins STH1 and STH2 by Streptococcus gordonii DL1 (Challis) is
directly controlled by the competence regulon, which requires intact comR and comAB loci …

Streptococcus mutans expresses comX (also known as sigX), which encodes a sigma factor
that is required for development of genetic competence, in response to the peptide signals …

Beta-hemolytic streptococci cause a variety of infectious diseases associated with high
morbidity and mortality. A key factor for successful infection is host colonization, which can …

All streptococcal genomes encode the alternative sigma factor SigX and 21 SigX-dependent
proteins required for genetic transformation, yet no pyogenic streptococci are known to …

Streptococcus pyogenes is a globally prominent bacterial pathogen that exhibits strict
tropism for the human host, yet bacterial factors responsible for the ability of S. pyogenes to …

The genome of Streptococcus mutans harbours 13 two-component signal transduction
systems (TCSTSs). Of these, a peptide-mediated quorum-sensing system, ComCDE, and …

The regulator VicR of the two-component regulatory system VicRK is essential in several
Gram-positive bacteria. However, the authors were able to generate an unconditional vicR …

Streptococcus intermedius is associated with deep-seated purulent infections. In this study,
we investigated expression and functional activities of antigen I/II in S. intermedius. The S …