CovR/CovS is an important two-component regulatory system in human pathogen group A
Streptococcus (GAS). Epidemiological studies have shown that inactivation of the sensor …

A novel growth phase‐associated two‐component‐type regulator, Fas (f
ibronectin/fibrinogen binding/haemolytic a ctivity/s treptokinase regulator), of Streptococcus …

The multiple sugar metabolism (msm) operon of Streptococcus mutans is responsible for the
uptake and metabolism of a variety of sugars. In order to further characterize the substrate …

Streptococcus mutans, a dental pathogen, encodes the ComDE two-component system
comprised of a histidine kinase (ComD) and a response regulator (ComE). This system is …

Streptococcus anginosus is increasingly recognized as an opportunistic pathogen.
However, our knowledge about virulence determinants in this species is scarce. One …

Horizontal gene transfer through natural DNA transformation is an important evolutionary
mechanism among bacteria. Transformation requires that the bacteria are physiologically …

Natural transformation increases the genetic diversity of bacteria, but is costly and must be
strictly controlled. We previously found that deletion of ccpA, a key regulator of carbon …

Bacterial morphology is largely determined by the spatial and temporal regulation of
peptidoglycan (PG) biosynthesis. Ovococci possess a unique pattern of PG synthesis …

In streptococcal species, the key step of competence development is the transcriptional
induction of comX, which encodes the alternative sigma factor σX, which positively regulates …

Trigger factor is a ribosome-associated peptidyl-prolyl cis/trans isomerase that is highly
conserved in most bacteria. A gene, designated ropA, encoding an apparent trigger factor …