Background: Recently, increased body weight has been associated with an increased risk of
cancers at multiple specific sites, including gastric cancer. Adiponectin is a peptide hormone …

The adipose tissue (AT) is severely affected by cachexia, a paraneoplastic syndrome, which
increases the morbidity and mortality of cancer. There is, however, a heterogeneous …

There is a pressing need for more effective appetite-stimulatory therapies for many patient
groups including those with cancer. We have previously demonstrated that the gastric …

Extensive loss of adipose tissue is a hallmark of cancer cachexia but the cellular and
molecular basis remains unclear. This study has examined morphologic and molecular …

Obesity and insulin resistance have been implicated in the etiology of pancreatic cancer
(PC). Whether adiponectin and/or leptin, two adipocyte-secreted hormones important in …

Up to 50% of cancer patients suffer from a progressive atrophy of adipose tissue and
skeletal muscle, called cachexia, resulting in weight loss, a reduced quality of life, and a …

The development of the syndrome of cancer cachexia and that of metastasis are related with
a poor prognostic for cancer patients. They are considered multifactorial processes …

The increasing percentage of obese individuals in the population and its independent
association of increased risk for the development of cancer have heightened the necessity to …

Adiponectin, a hormone secreted by adipose tissue, circulates at high concentrations in
human plasma. Paradoxically, plasma levels of adiponectin are approximately 50% lower in …

BACKGROUND. Cancer cachexia is an important, negative prognostic marker that has been
linked to systemic inflammation and cell death through unclear mechanisms. A key feature of …