Cancer and its morbidities, such as cancer cachexia, constitute a major public health
problem. Although cancer cachexia has afflicted humanity for centuries, its underlying …

A tumor extends its effects beyond its local site, and one such effect is cancer cachexia
which is caused by a state of systemic inflammation in response to cancer. Though the …

Cachexia has a devastating impact on survival and quality of life for many cancer patients. A
better understanding of the underlying mechanisms leading to the complex metabolic …

Progressive wasting is common in many types of cancer and is one of the most important
factors leading to the early death of cancer patients. Although anorexia frequently …

Purpose Overweight or obese breast cancer patients have a worse prognosis compared
with normal-weight patients. This may be attributed to hyperinsulinemia and dysregulation of …

Purpose Adipokines are linked to obesity and insulin sensitivity and have recently been
related to breast cancer risk and prognosis. We investigated the associations of plasma …

Adipose tissue-produced hormones significantly affect the metabolism of lipids and
carbohydrates as well as numerous other processes in human body. It is generally accepted …

Adipose tissue secretes adipokines with proinflammatory and anti-inflammatory properties.
Our aim was to assess the role of adipose tissue in generalized inflammatory state of …

Purpose Cachexia in cancer adversely affects patients' perception of symptoms, well-being,
and response to therapy, and shortens survival. Anamorelin, an oral mimetic of ghrelin, has …

Leptin is a recently identified hormone produced by the adipocyte ob gene which acts as a
negative feedback signal critical to the normal control of food intake and body weight. A …