Bruceine D elevates Nrf2 activation to restrain Parkinson's disease in mice through suppressing oxidative stress and inflammatory response

Y Yang, F Kong, Q Ding, Y Cai, Y Hao… - … and Biophysical Research …, 2020 - Elsevier
Parkinson's disease (PD) is neurodegenerative disease, featured by a loss of dopaminergic
neurons in the substantia nigra pars compacta (SNpc), characteristic motor symptoms and …

Activation of Nrf2 by methylene blue is associated with the neuroprotection against MPP+ induced toxicity via ameliorating oxidative stress and mitochondrial …

S Bhurtel, E Bok, N Katila, J Kim, DY Choi - Biochemical Pharmacology, 2021 - Elsevier
The neuropathological hallmark of Parkinson's disease (PD) is the preferential loss of
dopaminergic neurons in the substantia nigra and presence of Lewy bodies in the dying …

Ferulic Acid Ameliorates MPP+/MPTP-Induced Oxidative Stress via ERK1/2-Dependent Nrf2 Activation: Translational Implications for Parkinson Disease Treatment

X Li, J Zhang, H Rong, X Zhang, M Dong - Molecular neurobiology, 2020 - Springer
Parkinson's disease (PD) is a neurodegenerative disorder closely associated with oxidative
stress. The biochemical and cellular alterations that occur after cell and mouse treatment …

Berberine protects against NLRP3 inflammasome via ameliorating autophagic impairment in MPTP-induced Parkinson's disease model

S Huang, H Liu, Y Lin, M Liu, Y Li, H Mao… - Frontiers in …, 2021 - frontiersin.org
The NLR family pyrin domain containing 3 (NLRP3) inflammasome was reported to be
regulated by autophagy and activated during inflammatory procession of Parkinson's …

Nrf2 activator via interference of Nrf2-Keap1 interaction has antioxidant and anti-inflammatory properties in Parkinson's disease animal model

S Kim, ANI Viswanath, JH Park, HE Lee, AY Park… - …, 2020 - Elsevier
Parkinson's disease (PD) is a neurodegenerative disorder characterized by abnormal
movement, including slowed movements, shuffling gait, lack of balance, and tremor …

Hordenine inhibits neuroinflammation and exerts neuroprotective effects via inhibiting NF-κB and MAPK signaling pathways in vivo and in vitro

Y Su, Y Liu, D He, G Hu, H Wang, B Ye, Y He… - International …, 2022 - Elsevier
Parkinson's disease (PD) is a usual disease caused by degeneration of the central nervous
system, which features the denaturation and death of dopaminergic neurons in the …

Berberine activates Nrf2 nuclear translocation and protects against oxidative damage via a phosphatidylinositol 3-kinase/Akt-dependent mechanism in NSC34 motor …

YY Hsu, CS Chen, SN Wu, YJ Jong, YC Lo - European Journal of …, 2012 - Elsevier
Berberine (BBR) is a well-known anti-diabetic herbal medicine in Asia due to its beneficial
effects on insulin sensitivity, glucose metabolism and glycolysis. Here, we identified the …

Bushen‐yizhi formula alleviates neuroinflammation via inhibiting NLRP3 inflammasome activation in a mouse model of Parkinson's disease

Y Mo, E Xu, R Wei, B Le, L Song, D Li… - Evidence‐Based …, 2018 - Wiley Online Library
Parkinson's disease (PD), the second most common neurodegenerative disease, is
characterized by the progressive loss of dopaminergic neurons in the substantia nigra …

Demethylenetetrahydroberberine protects dopaminergic neurons in a mouse model of Parkinson's disease

WEN Jing, YQ Zhang, LIU Dong-Qing… - Chinese Journal of …, 2022 - Elsevier
Parkinson's disease (PD) is a multifactorial disorder of the nervous system where a
progressive loss of dopaminergic neurons exist. However, the pathogenesis of PD remains …

Puerarin suppresses MPP+/MPTP-induced oxidative stress through an Nrf2-dependent mechanism

X Li, J Zhang, X Zhang, M Dong - Food and Chemical Toxicology, 2020 - Elsevier
In this study, we hypothesized that anti-parkinsonian effect of puerarin is attributable to its
antioxidant properties via Nrf2-dependent glutathione (GSH) biosynthesis mechanism …