Elevated levels of Na and Cl in airway surface liquid may play a major role in the airway
pathology of cystic fibrosis (CF)(JJ Smith, SM Travis, EP Greenberg, and MJ Welsh. Cell 85 …

Cystic fibrosis (CF) is caused by the loss of functional CFTR Cl− channels. However, it is not
understood how this defect disrupts salt and liquid movement in the airway or whether it …

A novel isotopic technique suggests that the [Na] and [Cl] of airway surface liquid are both
normally~ 50 mM. In cystic fibrosis, lack of the functional cystic fibrosis transmembrane …

We have tested two hypotheses: 1) the cystic fibrosis transmembrane conductance regulator
(CFTR) represents the predominant Cl conductance in the apical membrane of human …

The cystic fibrosis transmembrane conductance regulator CFTR gene is found on
chromosome 7 [Kerem, B., Rommens, JM, Buchanan, JA, Markiewicz, D., Cox, TK …

An in vivo human bronchial xenograft model system was used to simultaneously analyze
electrolyte and fluid transport defects in fully differentiated human cystic fibrosis (CF) and …

Patients with cystic fibrosis (CF) demonstrate a characteristic defect in epithelial chloride
movement, which can be demonstrated in vivo by the nasal potential difference technique …

Cystic fibrosis (CF) airway epithelia exhibit defective transepithelial electrolyte transport:
cAMP-stimulated Cl-secretion is abolished because of the loss of apical membrane cystic …

Previous studies demonstrated that ACh-induced liquid secretion by porcine bronchi is
driven by active Cl− and H CO 3− secretion. The present study was undertaken to determine …

Electrolyte transport by airway epithelia regulates the quantity and composition of liquid
covering the airways. Previous data indicate that airway epithelia can absorb NaCl. At the …