Major histocompatibility complex (MHC) class II molecules display peptides to the T cell
receptor (TCR). The ability of the TCR to discriminate foreign from self-peptides presented …

While recent evidence strongly suggests that the third complementarity determining regions
(CDR3s) of T cell receptors (TCRs) directly contact antigenic peptides bound to major …

T cell receptors (TCR) recognize antigenic peptides displayed by MHC molecules. Whereas
T-cell recognition of foreign peptides is essential for immune defense against microbial …

The crystal structures of five autoimmune T cell receptor (TCR)–peptide–MHC complexes
reveal substantial structural alterations compared to antimicrobial TCRs. The two human …

The advent in recent years of the application of tetrameric arrays of class I peptide–MHC
complexes now enables us to detect and study rare populations of antigen‐specific CD8+ T …

We determined the crystal structures of the T cell receptor (TCR)-like antibody 25-D1. 16 Fab
fragment bound to a complex of SIINFEKL peptide from ovalbumin and the H-2K b molecule …

Cytotoxic T cells recognize mosaic structures consisting of target peptides embedded within
self-major histocompatibility complex (MHC) class I molecules. This structure has been …

Superantigens bind to major histocompatibility complex (MHC) class II proteins and interact
with variable parts of the T cell antigen receptor (TCR) β‐chain. Cross‐linking the TCR with …

The T cell receptor (TCR) orchestrates immune responses by binding to foreign peptides
presented at the cell surface in the context of major histocompatibility complex (MHC) …

Significant progress has been made on several long-standing issues regarding T-cell
receptor mediated recognition of antigen-MHC complexes. For one, early data suggest that …