With the continuous increase of the elderly population, there is an urgency to understand
and develop relevant treatments for Alzheimer's disease and related dementias (ADRD). In …

Neurodegenerative diseases are increasing in prevalence and place a significant burden on
society. The causes are multifactorial and complex, and increasing evidence suggests a …

Critical environmental factors like physical threats, air pollution, and infections, alongside
social determinants of health (SDH)(Ibáñez et al., 2023) such as social disparities …

Rich data from large biobanks, coupled with increasingly accessible association statistics
from genome-wide association studies (GWAS), provide great opportunities to dissect the …

INTRODUCTION Alzheimer's disease (AD) is the predominant dementia globally, with
heterogeneous presentation and penetrance of clinical symptoms, variable presence of …

Alzheimer's disease (AD) is a neurodegenerative disorder affecting nearly one in nine older
adults in the US. This number is expected to grow exponentially, thereby increasing stress …

INTRODUCTION Unraveling how Alzheimer's disease (AD) genetic risk is related to
neuropathological heterogeneity, and whether this occurs through specific biological …

Alzheimer's disease (AD) is the most common type of dementia, affecting millions of people
worldwide; however, no disease-modifying treatments are currently available. Genome-wide …

Since first described in the early 1900s, Alzheimer's disease (AD) has risen exponentially in
prevalence and concern. Research still drives to understand the etiology and pathogenesis …

Background Alzheimer's disease (AD), the most prevalent form of dementia, affects 6.5
million Americans and over 50 million people globally. Clinical, genetic, and phenotypic …