Context Loss-of-function mutations of makorin RING finger protein 3 (MKRN3) are the most
common monogenic cause of familial central precocious puberty (CPP). Objective To …

Background: Little is known about the genetic causes responsible for idiopathic central
precocious puberty (iCPP). More recently, described loss-of-function mutations in the …

Context: Loss-of-function mutations in makorin ring finger 3 (MKRN3), an imprinted gene
located on the long arm of chromosome 15, have been recognized recently as a cause of …

Context and objective Idiopathic central precocious puberty (iCPP) is defined as early
activation of the hypothalamic–pituitary–gonadal axis in the absence of identifiable central …

Background Central precocious puberty (CPP) is often familial but its genetic cause is
largely unknown. Very recently, the makorin RING finger protein 3 (MKRN3) gene, located …

Loss-of-function mutations in the gene encoding the makorin RING finger protein 3 (MKRN3)
have recently been reported to underlie familial cases of central precocious puberty (CPP) …

Purpose Recently, mutations of makorin RING-finger protein 3 (MKRN3) have been
described in familial central precocious puberty. Serum levels of this protein decline before …

MKRN3 mutations represent the most common genetic cause of central precocious puberty
(CPP) but associations between genotype and clinical features have not been extensively …

Objective: There have been recent advances in the understanding of the etiology of
idiopathic central precocious puberty (iCPP) including new genetic associations. The aim of …

Context: Central precocious puberty (CPP), defined as the development of secondary sex
characteristics prior to age 8 years in girls and 9 years in boys, results from the premature …