Plasma kallikrein inhibitors in cardiovascular disease: an innovative therapeutic approach

D Kolte, Z Shariat-Madar - Cardiology in Review, 2016 - journals.lww.com
Plasma prekallikrein is the liver-derived precursor of the trypsin-like serine protease plasma
kallikrein, and circulates in plasma bound to high molecular weight kininogen. Plasma …

Plasma kallikrein: the bradykinin-producing enzyme

J Björkqvist, A Jämsä, T Renné - Thrombosis and haemostasis, 2013 - thieme-connect.com
Plasma prekallikrein is the liver-derived precursor of the trypsin-like serine protease plasma
kallikrein (PK) and circulates in plasma bound to high molecular weight kininogen. The …

Plasma kallikrein: novel functions for an old protease

T Renné, A Gruber - Thrombosis and haemostasis, 2012 - thieme-connect.com
Plasma kallikrein (PK) is a plasma protease that drives procoagulant-and proinflammatory
reactions via the intrinsic pathway of coagulation and the kallikrein-kinin system …

Human plasma kallikrein: roles in coagulation, fibrinolysis, inflammation pathways, and beyond

G Motta, L Juliano, JR Chagas - Frontiers in Physiology, 2023 - frontiersin.org
Human plasma kallikrein (PKa) is obtained by activating its precursor, prekallikrein (PK),
historically named the Fletcher factor. Human PKa and tissue kallikreins are serine …

Role of plasma kallikrein in diabetes and metabolism

EP Feener, Q Zhou, W Fickweiler - Thrombosis and …, 2013 - thieme-connect.com
Plasma kallikrein (PK) is a serine protease generated from plasma prekallikrein, an
abundant circulating zymogen expressed by the Klkb1 gene. The physiological actions of …

Human tissue kallikrein: a new bullet for the treatment of ischemia

C Emanueli, P Madeddu - Current Pharmaceutical Design, 2003 - ingentaconnect.com
Recently, therapeutic angiogenesis has been proposed as an alternative for the treatment of
ischemic diseases unresponsive to conventional therapy. This strategy is based on the …

Small molecule inhibitors of plasma kallikrein

WB Young, R Rai, WD Shrader… - Bioorganic & medicinal …, 2006 - Elsevier
Plasma kallikrein is a serine protease that is involved in pathways of inflammation,
complement fixation, coagulation, and fibrinolysis. Herein, we describe the SAR and …

Plasma Kallikrein as a forgotten clotting factor

KJ Kearney, HMH Spronk, J Emsley… - … in Thrombosis and …, 2023 - thieme-connect.com
For decades, it was considered that plasma kallikrein's (PKa) sole function within the
coagulation cascade is the activation of factor (F) XII. Until recently, the two key known …

Aminopyridine derivatives as plasma kallikrein inhibitors

T Brandl, S Flohr, C Markert, K Namoto… - US Patent App. 14 …, 2014 - Google Patents
0002 Plasmakallikrein (PK) is the activated form of the trypsin-like serine protease plasma-
prokallikrein and is mainly expressed by hepatocytes in the liver. Activation of plasma …

Kallikrein activates prothrombin

TW Stief - Clinical and Applied Thrombosis/Hemostasis, 2008 - journals.sagepub.com
Kallikrein is a multitalented enzyme in hemostasis and inflammation. Normally, kallikrein is
formed in intrinsic hemostasis and activates factor XII. A total of 10 µL of 0 to 100 µg/mL …