Deletion of the innate immune adaptor myeloid differentiation primary response gene 88
(MyD88) in the nonobese diabetic (NOD) mouse model of type 1 diabetes (T1D) results in …

The incidence of type 1 diabetes (T1D) is determined by both genetic and environmental
factors. In recent years, the gut microbiota have been identified to be an important …

Abstract Type 1 diabetes (T1D) is a debilitating autoimmune disease that results from T-cell-
mediated destruction of insulin-producing β-cells. Its incidence has increased during the …

The composition of the gut microbiome represents a very important environmental factor that
influences the development of type 1 diabetes (T1D). We have previously shown that MyD88 …

Commensal flora and pathogenic microbes influence the incidence of diabetes in animal
models yet little is known about the mechanistic basis of these interactions. We …

Both animal model and human studies indicate that commensal bacteria may modify type 1
diabetes (T1D) development. However, the underlying mechanisms by which gut microbes …

RIP-B7. 1 transgenic mice express B7. 1 costimulatory molecules in pancreatic islets and
develop diabetes after treatment with polyinosinic: polycytidylic acid (poly I: C), a synthetic …

Background Dysbiosis of the gut microbiota has been implicated in the pathogenesis of
many autoimmune conditions including type 1 diabetes (T1D). It is unknown whether …

Type 1 diabetes (T1D) is an autoimmune disease that is triggered by both genetic and
environmental factors, resulting in the destruction of pancreatic β cells. The disruption of the …

Environmental factors and host genetics interact to control the gut microbiota, which may
have a role in the development of obesity and insulin resistance. TLR2-deficient mice, under …