Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2
T Kamijo, JD Weber, G Zambetti… - Proceedings of the …, 1998 - National Acad Sciences
The INK4a-ARF locus encodes two proteins, p16INK4a and p19ARF, that restrain cell
growth by affecting the functions of the retinoblastoma protein and p53, respectively …
growth by affecting the functions of the retinoblastoma protein and p53, respectively …
p19ARF is dispensable for oncogenic stress-induced p53-mediated apoptosis and tumor suppression in vivo
D Tolbert, X Lu, C Yin, M Tantama… - Molecular and cellular …, 2002 - Am Soc Microbiol
Recent studies have shown the p19 ARF tumor suppressor to be involved in the response to
oncogenic stress by regulating the activity of p53. This response is mediated by …
oncogenic stress by regulating the activity of p53. This response is mediated by …
p53-Dependent and-independent functions of the Arf tumor suppressor
CJ Sherr, D Bertwistle, W Den Besten… - Cold Spring Harbor …, 2005 - symposium.cshlp.org
Abstract The Ink4a-Arf locus encodes two closely wedded tumor suppressor proteins (p16
Ink4a and p19 Arf) that inhibit cell proliferationby activating Rb and p53, respectively. With …
Ink4a and p19 Arf) that inhibit cell proliferationby activating Rb and p53, respectively. With …
Nucleolar Arf sequesters Mdm2 and activates p53
JD Weber, LJ Taylor, MF Roussel, CJ Sherr… - Nature cell …, 1999 - nature.com
Abstract The Ink4/Arf locus encodes two tumour-suppressor proteins, p16 Ink4a and p19 Arf,
that govern the antiproliferative functions of the retinoblastoma and p53 proteins …
that govern the antiproliferative functions of the retinoblastoma and p53 proteins …
ARF function does not require p53 stabilization or Mdm2 relocalization
C Korgaonkar, L Zhao, M Modestou… - Molecular and cellular …, 2002 - Am Soc Microbiol
It is generally accepted that the ARF tumor suppressor induces p53-dependent growth arrest
by sequestering the p53 antagonist Mdm2 in the nucleolus. Previous mutagenic studies of …
by sequestering the p53 antagonist Mdm2 in the nucleolus. Previous mutagenic studies of …
ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways
The INK4a-ARF locus encodes two unrelated proteins that both function in tumor
suppression. p16 INK4a binds to and inhibits the activity of CDK4 and CDK6, and ARF …
suppression. p16 INK4a binds to and inhibits the activity of CDK4 and CDK6, and ARF …
p14ARF induces G2 arrest and apoptosis independently of p53 leading to regression of tumours established in nude mice
B Eymin, C Leduc, JL Coll, E Brambilla, S Gazzeri - Oncogene, 2003 - nature.com
Until recently, the ability of ARF (human p14 ARF, murine p19 ARF) tumour-suppressor
protein, encoded by the INK4A/ARF locus, to inhibit cell growth in response to various stimuli …
protein, encoded by the INK4A/ARF locus, to inhibit cell growth in response to various stimuli …
Mutations in human ARF exon 2 disrupt its nucleolar localization and impair its ability to block nuclear export of MDM2 and p53
The mammalian ARF-INK4a locus uniquely encodes two cell cycle inhibitors by using
separate promoters and alternative reading frames. p16 INK4a maintains the retinoblastoma …
separate promoters and alternative reading frames. p16 INK4a maintains the retinoblastoma …
Arf tumor suppressor promoter monitors latent oncogenic signals in vivo
F Zindy, RT Williams, TA Baudino… - Proceedings of the …, 2003 - National Acad Sciences
Induction of the Arf tumor suppressor gene by elevated thresholds of mitogenic signals
activates a p53-dependent transcriptional response that triggers either growth arrest or …
activates a p53-dependent transcriptional response that triggers either growth arrest or …
Arf induces p53-dependent and-independent antiproliferative genes
ML Kuo, EJ Duncavage, R Mathew, W Den Besten… - Cancer Research, 2003 - AACR
The tumor suppressor p19Arf (p14ARF in humans), encoded by the Ink4a/Arf locus, is
mutated, deleted, or silenced in many forms of cancer. p19Arf induces growth arrest by …
mutated, deleted, or silenced in many forms of cancer. p19Arf induces growth arrest by …