Objectives Opiorphin is a pentapeptide isolated from human saliva that suppresses pain
from chemically induced inflammation and acute physical pain. Burning mouth syndrome …

Abstract Objectives Idiopathic Burning mouth syndrome (iBMS) is a poorly understood
affection characterized by persistent pain in the oral cavity without any clinical or biological …

Objectives: Opiorphin is an enkephalinase inhibitor which suppresses pain by acting on the
opioid system. The levels of opiorphin in plasma and saliva have shown to vary in patients …

Objectives Opiorphin is a recently discovered peptide shown to inhibit the enkephalin-
degrading enzymes and prolong the effects of enkephalins. Although opiorphin is found in …

Objective Opiorphin is a pentapeptide secreted in saliva and has a strong analgesic effect.
Salivary opiorphin has been shown to increase in orofacial pain and may act as a pain …

Purpose This study aimed at assessing the change in salivary opiorphin levels before and
after administration of local anesthesia, with the use of three different local anesthetic …

Objectives: Opiorphin is a physiological inhibitor of peptidases inactivating endogenous
opioids displaying strong analgesic properties without undesirable side effects …

Opiorphin, QRFSR-peptide, is a mature product of the PROL1 (proline rich, lacrimal 1)
protein that showed beneficial effects in pain management, antidepressant-like actions as …

Background Burning mouth syndrome (BMS) is a neuropathic orofacial pain condition of
unknown aetiology that encompasses intra‐oral burning pain without abnormal clinical …

Objective Burning mouth syndrome (BMS) and atypical odontalgia (AO) are examples of
somatic symptom disorders with predominant pain around the orofacial region …