Looking inside the matrix: perineuronal nets in plasticity, maladaptive plasticity and neurological disorders

C De Luca, M Papa - Neurochemical Research, 2016 - Springer
The integrity of the central nervous system (CNS) matrix is crucial for its proper function.
Loss of the lattice-like structure compromise synaptic stability and can lead to the disruption …

Perineuronal nets and their role in synaptic homeostasis

M Bosiacki, M Gąssowska-Dobrowolska… - International journal of …, 2019 - mdpi.com
Extracellular matrix (ECM) molecules that are released by neurons and glial cells form
perineuronal nets (PNNs) and modulate many neuronal and glial functions. PNNs, whose …

[HTML][HTML] Perineuronal nets and CNS plasticity and repair

D Carulli, JCF Kwok, T Pizzorusso - Neural Plasticity, 2016 - ncbi.nlm.nih.gov
The extracellular matrix (ECM) of the nervous system regulates numerous events during
development, from neurogenesis and gliogenesis to circuitry formation, as well as in …

Matrix metalloproteinases, neural extracellular matrix, and central nervous system pathology

C De Luca, M Papa - Progress in molecular biology and translational …, 2017 - Elsevier
The functionality and stability of the central nervous system (CNS) pabulum, called neural
extracellular matrix (nECM), is paramount for the maintenance of a healthy network. The …

A glial perspective on the extracellular matrix and perineuronal net remodeling in the central nervous system

BP Tewari, L Chaunsali, CE Prim… - Frontiers in cellular …, 2022 - frontiersin.org
A structural scaffold embedding brain cells and vasculature is known as extracellular matrix
(ECM). The physical appearance of ECM in the central nervous system (CNS) ranges from a …

Protective properties of neural extracellular matrix

A Suttkus, M Morawski, T Arendt - Molecular neurobiology, 2016 - Springer
The extracellular matrix (ECM) of the central nervous system (CNS) occupies a large part of
the neural tissue. It serves a variety of functions ranging from support of cell migration and …

Perineuronal nets: Cruise from a honeycomb to the safety nets

U John, N Patro, I Patro - Brain Research Bulletin, 2022 - Elsevier
The extracellular matrix (ECM) is a significant component of the brain, constituting up to 20%
of the brain volume and perform multifarious functions during development, maturation and …

The perineuronal 'safety'net? Perineuronal net abnormalities in neurological disorders

TH Wen, DK Binder, IM Ethell… - Frontiers in molecular …, 2018 - frontiersin.org
Perineuronal nets (PNN) are extracellular matrix (ECM) assemblies that preferentially
ensheath parvalbumin (PV) expressing interneurons. Converging evidence indicates that …

The brain's extracellular matrix and its role in synaptic plasticity

R Frischknecht, ED Gundelfinger - Synaptic Plasticity: Dynamics …, 2012 - Springer
The extracellular matrix (ECM) of the brain has important roles in regulating synaptic
function and plasticity. A juvenile ECM supports the wiring of neuronal networks …

From molecules to behavior: Implications for perineuronal net remodeling in learning and memory

B Sanchez, P Kraszewski, S Lee… - Journal of …, 2023 - Wiley Online Library
Perineuronal nets (PNNs) are condensed extracellular matrix (ECM) structures found
throughout the central nervous system that regulate plasticity. They consist of a …