Among the Plasmodium falciparum surface antigens reported by Richard Carter and his
colleagues decades ago, Pfs230 is currently the target of the most advanced candidate for a …

In the early 1980s, Richard Carter was among the first researchers to identify the sexual
stage-specific Pfs48/45 protein, leading to the identification of target epitopes. Carter …

Acknowledging the fallibilities of recalling events from more than three decades ago, the
recollection of Richard Carter's impact on the identification and development of Pfs25, a …

Transmission-blocking vaccines (TBVs), pioneered by Richard Carter and others, aim to
prevent parasite development in the mosquito vector and are a promising new tool for …

Background Control and elimination of malaria can be accelerated by transmission-blocking
interventions such as vaccines. A surface antigen of Plasmodium falciparum gametocytes …

Pfs230 is essential for Plasmodium falciparum transmission to mosquitoes and is the protein
targeted by the most advanced malaria-transmission-blocking vaccine candidate. Prior …

Plasmodium falciparum is transmitted to a new host after completing its sexual cycle within a
mosquito. Developing vaccines against the parasite sexual stages is a critical component in …

Transmission-blocking vaccines are based on eliciting antibody responses in the vertebrate
host that disrupt parasite development in the mosquito vector and prevent malaria …

Malaria transmission-blocking vaccines (TBVs) aim to induce antibodies that interrupt
malaria parasite development in the mosquito, thereby blocking onward transmission, and …

Pfs25 is a sexual stage antigen of Plasmodium falciparum that is expressed on the surface
of zygote and ookinete forms of the parasite. Monoclonal antibodies directed against native …