Secreted frizzled related protein 1 (SFRP1) is an antagonist of the transmembrane frizzled
receptor, a component of the Wnt signaling pathway, and has been suggested to be a …

Epigenetic silencing of secreted frizzled-related protein (SFRP) genes, antagonists of the
WNT pathway, contributes to the pathogenesis of several cancers including non-small cell …

Secreted frizzled related protein 3 (SFRP3) contains a cysteine-rich domain (CRD) that
shares homology with Frizzled CRD and regulates WNT signaling. Independent studies …

Secreted frizzled-related protein 1 (SFRP1) is a gene that belongs to the secreted
glycoprotein SFRP family. SFRP1 has been classified as a tumor suppressor gene due to …

The Wnt (wingless-type) signaling pathway plays an important role in embryonic
development, tissue homeostasis, and tumor progression becaluse of its effect on cell …

Expression of Secreted frizzled related protein 1 (SFRP1), a recently identified tumor
suppressor gene encoding a WNT signaling antagonist, has been found to be frequently …

Secreted frizzled-related proteins (SFRPs), containing five family members (SFRPs 1–5) are
putative extracellular Wnt inhibitors. Given their abilities to inhibit Wnt signalling, as well as …

Secreted frizzled-related protein 1 (SFRP1) is a candidate tumor suppressor gene located at
8p11. 2 and antagonizes the Wnt signaling pathway. Epigenetic inactivation of SFRP1 by …

The Wnt signaling pathway is implicated in a variety of biological processes ranging from
developmental cell fate to human disease. The components involved in Wnt signaling have …

BACKGROUND. The secreted frizzled‐related protein 1 gene (SFRP1) encodes a Wnt/β‐
catenin signaling antagonist and frequently is inactivated by promoter methylation in many …