We showed recently that deletion of a strong enhancer located 2.7 kb upstream of the renin
gene in mice produces a strain with mild hypotension and salt-sensitivity. Here we set out to …

The important cardiovascular regulator renin contains a strong in vitro enhancer 2.7 kb
upstream of its gene. Here we tested the in vivo role of the mouse Ren-1 c enhancer. In …

Renin, a major regulatory component of the renin-angiotensin system, plays a pivotal role in
regulating blood pressure and electrolyte homeostasis and is predominantly expressed in …

In the kidney, renin gene expression is exquisitely localized to the juxtaglomerular (JG) cells
lining the afferent arteriole, having the capacity to regulate renin synthesis in response to a …

The renin-angiotensin system plays a major role in the regulation of blood pressure and
electrolyte homeostasis in mammals. In this study, we subjected transgenic mice containing …

To create physiological models of the human renin-angiotensin system in transgenic
animals, the component genes should be expressed in the correct tissues and cells and …

Renin is the rate-limiting enzyme in the renin-angiotensin system and thus dictates the level
of the pressor hormone angiotensin-II. The classical site of renin expression and secretion is …

Objective: To obtain information about possible pathways mediating the suppression of
renin gene expression in the contralateral kidneys of stenosed kidneys. Design: The effects …

Renin, as a component of the renin-angiotensin system, plays important roles in the
regulation of blood pressure, electrolyte homeostasis, and mammalian renal development …

Renin plays a central role in controlling blood pressure as it catalyzes the first step in the
production of angiotensin II. The aim of this study was to isolate fragments of the human …