Despite the fact that the use of alcohol, nicotine and other drugs is the major external factor
contributing to mortality in industrialised countries, there are few medications available to …

The most challenging aspect of treating alcohol and drug addiction is the relapsing course of
these disorders. Although substitution therapies for nicotine and opioid dependence have …

Long-term alcohol exposure leads to the development of alcohol dependence, which is
possibly induced by changes in specific neurotransmitter functions. Accumulating evidence …

New animal models have been developed which mimic several aspects of alcoholism.
These models provide the basis to study the neurobiological mechanisms of" addicted …

Abstract N-methyl-D-aspartate (NMDA) receptors mediate a slow component of excitatory
synaptic transmission, are widely distributed throughout the central nervous system, and …

Because of its widespread involvement in the physiology and pathology of the CNS, the
glutamatergic system has gained considerable attention as a potential target for …

NMDA receptors are ionotropic receptors mediating glutamatergic neurotransmission and
play a role in several basic functions in the central nervous system, from regulating …

This paper reviews clinical evidence suggesting that antagonism of the N‐methyl‐d‐
aspartate subtype of glutamate receptors by ethanol may convey an important component of …

The NMDA receptor (NMDAR) family of l-glutamate receptors are well known to have
diverse roles in CNS function as well as in various neuropathological and psychiatric …

Glutamate plays a pivotal role in drug addiction, and the N-methyl-d-aspartate (NMDA)
glutamate receptor subtype serves as a molecular target for several drugs of abuse. In this …