The role of magnesium ions in bone regeneration involves the canonical Wnt signaling pathway

CC Hung, A Chaya, K Liu, K Verdelis, C Sfeir - Acta biomaterialia, 2019 - Elsevier
Magnesium (Mg)-based implants have become of interest to both academia and the medical
industry. The attraction largely is due to Mg's biodegradability and ability to enhance bone …

Magnesium ion stimulation of bone marrow stromal cells enhances osteogenic activity, simulating the effect of magnesium alloy degradation

S Yoshizawa, A Brown, A Barchowsky, C Sfeir - Acta biomaterialia, 2014 - Elsevier
Magnesium alloys are being investigated for load-bearing bone fixation devices due to their
initial mechanical strength, modulus similar to native bone, biocompatibility and ability to …

[HTML][HTML] Magnesium Chloride promotes Osteogenesis through Notch signaling activation and expansion of Mesenchymal Stem Cells

JM Díaz-Tocados, C Herencia, JM Martínez-Moreno… - Scientific reports, 2017 - nature.com
Mesenchymal stem cells (MSC) are osteoblasts progenitors and a variety of studies suggest
that they may play an important role for the health in the field of bone regeneration …

Role of magnesium ions on osteogenic response in bone marrow stromal cells

S Yoshizawa, A Brown, A Barchowsky… - Connective tissue …, 2014 - Taylor & Francis
Biodegradable magnesium (Mg) alloys have been investigated for craniofacial and
orthopedic bone fracture fixation due to their initial mechanical strength and high …

[HTML][HTML] Development of degradable magnesium-based metal implants and their function in promoting bone metabolism (A review)

Z Shan, X Xie, X Wu, S Zhuang, C Zhang - Journal of Orthopaedic …, 2022 - Elsevier
Background Use of degradable magnesium (Mg)-based metal implants in orthopaedic
surgeries can avoid drawbacks associated with subsequent removal of the non-degradable …

Unraveling the osteogenesis of magnesium by the activity of osteoblasts in vitro

Y Wang, Z Geng, Y Huang, Z Jia, Z Cui, Z Li… - Journal of Materials …, 2018 - pubs.rsc.org
Magnesium (Mg) alloys, having a unique combination of strength and degradation, are
being explored for various craniofacial and orthopedic applications. Nevertheless, the …

Magnesium ions promote the biological behaviour of rat calvarial osteoblasts by activating the PI3K/Akt signalling pathway

J Wang, XY Ma, YF Feng, ZS Ma, TC Ma… - Biological trace element …, 2017 - Springer
Magnesium has been investigated as a biodegradable metallic material. Increased
concentrations of Mg 2+ around magnesium implants due to biodegradation contribute to its …

[HTML][HTML] Magnesium-based biomaterials as emerging agents for bone repair and regeneration: From mechanism to application

H Zhou, B Liang, H Jiang, Z Deng, K Yu - Journal of Magnesium and Alloys, 2021 - Elsevier
Magnesium (Mg) is the fourth most abundant element in the human body and is important in
terms of specific osteogenesis functions. Here, we provide a comprehensive review of the …

Magnesium promotes bone formation and angiogenesis by enhancing MC3T3-E1 secretion of PDGF-BB

W Liu, S Guo, Z Tang, X Wei, P Gao, N Wang… - Biochemical and …, 2020 - Elsevier
Although magnesium and its alloys are candidates for orthopedic implants, they can
effectively promote osteogenesis and angiogenesis. However, due to the degradability of …

Magnesium enhances osteogenesis of BMSCs by tuning osteoimmunomodulation

X Zhang, Q Chen, X Mao - BioMed research international, 2019 - Wiley Online Library
In the process of bone tissue engineering, the osteoimmunomodulatory property of
biomaterials is very important for osteogenic differentiation of stem cells, which determines …