Long-term reciprocal changes in dopamine levels in prefrontal cortex versus nucleus accumbens in rats born by Caesarean section compared to vaginal birth

BF El-Khodor, P Boksa - Experimental neurology, 1997 - Elsevier
Epidemiological evidence indicates a higher incidence of pregnancy and birth complications
among individuals who later develop schizophrenia, a disorder linked to alterations in …

Caesarean section birth with general anesthesia increases dopamine-mediated behavior in the adult rat

C Vaillancourt, P Boksa - Neuroreport, 1998 - journals.lww.com
SCHIZOPHRENIA is associated with both increased dopaminergic activity and perinatal
complications. To test whether dopamine-mediated behavior can be altered by birth …

Birth insult alters dopamine-mediated behavior in a precocial species, the guinea pig: Implications for schizophrenia

C Vaillancourt, P Boksa - Neuropsychopharmacology, 2000 - Elsevier
Schizophrenia is associated with increased birth complications, suggesting that birth
complications might alter CNS dopaminergic activity later in life. In rats, Caesarean section …

Epinephrine administration at birth prevents long-term changes in dopaminergic parameters caused by Cesarean section birth in the rat

P Boksa, Y Zhang - Psychopharmacology, 2008 - Springer
Rationale Obstetric complications involving birth hypoxia are implicated in the etiology of
disorders with dopaminergic dysfunction, such as schizophrenia. Cesarean section (C …

Birth insult increases amphetamine-induced behavioral responses in the adult rat

BF El-Khodor, P Boksa - Neuroscience, 1998 - Elsevier
We have previously reported that an apparently uncomplicated Caesarean section birth
produces long-term alterations in steady-state levels of dopamine in the central nervous …

Disruption of neurogenesis on gestational day 17 in the rat causes behavioral changes relevant to positive and negative schizophrenia symptoms and alters …

P Flagstad, A Mørk, BY Glenthøj, J Van Beek… - …, 2004 - nature.com
Gestational disruption of neurodevelopment has been proposed to lead to
pathophysiological changes similar to those underlying schizophrenia. We induced such …

Birth insult interacts with stress at adulthood to alter dopaminergic function in animal models: possible implications for schizophrenia and other disorders

P Boksa, BF El-Khodor - Neuroscience & Biobehavioral Reviews, 2003 - Elsevier
Altered subcortical dopaminergic activity is thought to be involved in the pathophysiology of
several disorders including schizophrenia, substance abuse and attention deficit …

Short-and long-term effects of perinatal asphyxia on monoamine, amino acid and glycolysis product levels measured in the basal ganglia of the rat

Y Chen, E Engidawork, F Loidl, E Dell'Anna… - Developmental brain …, 1997 - Elsevier
The effects of perinatal asphyxia on levels of dopamine (DA) and its metabolites, amino
acids and glycolysis products, measured in tissue samples from substantia nigra (SN) …

Perinatal distress leads to lateralized medial prefrontal cortical dopamine hypofunction in adult rats

WG Brake, RM Sullivan, A Gratton - Journal of Neuroscience, 2000 - Soc Neuroscience
Obstetric complications involving anoxia or prolonged hypoxia are suspected to increase the
risk for such mental disorders as schizophrenia and attention deficit–hyperactivity disorder …

Dopamine D1 receptor changes due to caesarean section birth: effects of anesthesia, developmental time course, and functional consequences

P Boksa, Y Zhang, A Bestawros - Experimental Neurology, 2002 - Elsevier
There is an epidemiological association between increased obstetric complications and
disorders involving CNS dopamine dysregulation, such as schizophrenia. In light of this, a …