Thus a participation of carnitine in metabolism by forming another type of" activated" acetic
acid was directly demonstrated. On the other hand carnitine had been shown to be a …

In the earlier work on the oxidation of fatty acids in vitro only fatty acids of short chain length
could be utilized with an appreciable activity xs. The stimulating effect of carnitine on the …

Friedman and Fraenkel (3) found that carnitine is acetylated enzymically by soluble extracts
of liver in the presence of acetate, adenosine triphosphate, and coenzyme A. When …

1. Pyruvate and a number of other α-keto acids have been used as substrates for the
acylation of carnitine by intact mammalian mitochondria. Acetyl-and/or propionylcarnitine …

Some properties of carnitine acetyltransferase activity in extracts of various animal tissues
and in intact mitochondria have been studied. Enzyme activity was found as soluble and …

The effect of (-)-carnitine on the conversion of citrate-1-14 C and pyruvate-2-14 C to 14 CO 2
and either 14 C-fatty acids or 14 C-acetylsulfanilamide was studied in pigeon liver …

The carnitine acetyltransferase and glutamate dehydrogenase activities of guinea-pig liver
and other tissues were estimated. Both enzymes are wholly mitochondrial, and can only be …

Recently, we reported that carnitine may be reversibly acetylated by mitochondria from
several tissues of the rat. When acetylcarnitine is deacetylated, a concomitant oxygen …

Acetylcarnitine added in catalytic amounts to kidney mitochondria produces an active
oxidation of endogenous fatty acids. 2. In conditions of mitochondrialaging', under which …

Subsequent reports from our laboratory showed that both carnitine (/3-hydroxy-y-
trimethylammonium butyrate) and acetylcarnitinei increased oxygen uptake and oxidation of …