Dabigatran concentration: variability and potential bleeding prediction in “real–life” patients with atrial fibrillation

P Šinigoj, RE Malmström, N Vene… - Basic & clinical …, 2015 - Wiley Online Library
Routine laboratory monitoring is currently not recommended in patients receiving dabigatran
despite its considerable variation in plasma concentration. However, in certain clinical …

Real‐world variability in dabigatran levels in patients with atrial fibrillation

NC Chan, M Coppens, J Hirsh… - … of Thrombosis and …, 2015 - Wiley Online Library
Background In clinical practice, physicians are given the choice of selecting one of two
dabigatran doses based on patient characteristics, with the lower dose typically used in …

A proposal for dose‐adjustment of dabigatran etexilate in atrial fibrillation guided by thrombin time

PKL Chin, DFB Wright, DM Patterson… - British journal of …, 2014 - Wiley Online Library
Dabigatran is an oral anticoagulant that is increasingly used for atrial fibrillation (AF).
Presently, many authorities state that routine laboratory coagulation monitoring is not …

On the monitoring of dabigatran treatment in “real life” patients with atrial fibrillation

M Skeppholm, P Hjemdahl, JP Antovic, J Muhrbeck… - Thrombosis research, 2014 - Elsevier
Introduction The oral direct thrombin inhibitor dabigatran is increasingly used to prevent
thromboembolic stroke in patients with atrial fibrillation (AF). Routine laboratory monitoring is …

Evaluation of coagulation assays versus LC-MS/MS for determinations of dabigatran concentrations in plasma

JP Antovic, M Skeppholm, J Eintrei, EE Boija… - European journal of …, 2013 - Springer
Background Dabigatran is an oral direct thrombin inhibitor for which routine laboratory
monitoring is currently not recommended. However, there are situations in which …

Monitoring of dabigatran therapy using Hemoclot® Thrombin Inhibitor assay in patients with atrial fibrillation

M Samoš, L Stančiaková, J Ivanková, J Staško… - Journal of thrombosis …, 2015 - Springer
Dabigatran, a new direct thrombin inhibitor, achieves strong anticoagulation that is more
predictable than warfarin. Nevertheless, a patient on dabigatran therapy (DT) may suffer …

Relation between dabigatran concentration, as assessed using the direct thrombin inhibitor assay, and activated clotting time/activated partial thromboplastin time in …

K Okubo, T Kuwahara, K Takagi, M Takigawa… - The American Journal of …, 2015 - Elsevier
Dabigatran is a direct thrombin inhibitor that has been approved for preventing stroke in
patients with atrial fibrillation. In this study, we aimed to assess the associations between the …

Coagulation assays and plasma fibrinogen concentrations in real‐world patients with atrial fibrillation treated with dabigatran

PKL Chin, DM Patterson, M Zhang… - British journal of …, 2014 - Wiley Online Library
Aims In patients with atrial fibrillation prescribed dabigatran, the aim was to examine the
correlation between plasma dabigatran concentrations and the three screening coagulation …

Diluted thrombin time reliably measures low to intermediate plasma dabigatran concentrations

M Božič-Mijovski, RE Malmström… - Annals of clinical …, 2016 - journals.sagepub.com
Background Direct oral anticoagulant dabigatran was first introduced as a fixed-dose drug
without routine coagulation monitoring, but current recommendations suggest that diluted …

Interference of the new oral anticoagulant dabigatran with frequently used coagulation tests

WM Halbmayer, G Weigel, P Quehenberger… - Clinical Chemistry and …, 2012 - degruyter.com
Background: Dabigatran etexilate is a new oral anticoagulant for the therapy and
prophylaxis of venous thromboembolism and stroke prevention in patients with atrial …