Use of integrative epigenetic and mRNA expression analyses to identify significantly changed genes and functional pathways in osteoarthritic cartilage

A He, Y Ning, Y Wen, Y Cai, K Xu, J Han… - Bone & joint …, 2018 - boneandjoint.org.uk
Aim Osteoarthritis (OA) is caused by complex interactions between genetic and
environmental factors. Epigenetic mechanisms control the expression of genes and are …

Genome‐wide DNA methylation study identifies significant epigenomic changes in osteoarthritic cartilage

MA Jeffries, M Donica, LW Baker… - Arthritis & …, 2014 - Wiley Online Library
Objective To perform a genome‐wide DNA methylation study to identify DNA methylation
changes in osteoarthritic (OA) cartilage tissue. Methods The contribution of differentially …

Analysis of methylation datasets identified significantly changed genes and functional pathways in osteoarthritis

B Han, Z Zheng, J Ren, W Qiu, X Li - Clinical Rheumatology, 2019 - Springer
Background Researches indicate that epigenetics was involved in osteoarthritis (OA). The
purpose of this study was to describe the alterations of DNA methylation in hip and knee OA …

Knee and hip articular cartilage have distinct epigenomic landscapes: implications for future cartilage regeneration approaches

W Den Hollander, YFM Ramos, SD Bos… - Annals of the …, 2014 - ard.bmj.com
Objectives To elucidate the functional epigenomic landscape of articular cartilage in
osteoarthritis (OA) affected knee and hip joints in relation to gene expression. Methods …

Analysis of mRNA expression and DNA methylation datasets according to the genomic distribution of CpG sites in osteoarthritis

P Yi, X Xu, J Yao, B Qiu - Frontiers in Genetics, 2021 - frontiersin.org
Objectives Transcriptional changes in cartilage can impact function by causing degradation
such as that which occurs during the development of osteoarthritis (OA). Epigenetic …

A Pilot Analysis of Genome‐Wide DNA Methylation Patterns in Mouse Cartilage Reveals Overlapping Epigenetic Signatures of Aging and Osteoarthritis

V Izda, CM Dunn, E Prinz, L Schlupp… - ACR Open …, 2022 - Wiley Online Library
Objective Cartilage epigenetic changes are strongly associated with human osteoarthritis
(OA). However, the influence of individual environmental OA risk factors on these epigenetic …

Genome‐wide DNA methylation study identifies significant epigenomic changes in osteoarthritic subchondral bone and similarity to overlying cartilage

MA Jeffries, M Donica, LW Baker… - Arthritis & …, 2016 - Wiley Online Library
Objective To perform a genome‐wide DNA methylation study to identify differential DNA
methylation patterns in subchondral bone underlying eroded and intact cartilage from …

Genome-wide DNA methylation study of hip and knee cartilage reveals embryonic organ and skeletal system morphogenesis as major pathways involved in …

E Aref-Eshghi, Y Zhang, M Liu, PE Harper… - BMC musculoskeletal …, 2015 - Springer
Background Evidence suggests that epigenetics plays a role in osteoarthrits (OA). The aim
of the study was to describethe genome wide DNA methylation changes in hip and knee OA …

Increased DNA methylation and reduced expression of transcription factors in human osteoarthritis cartilage

O Alvarez‐Garcia, KM Fisch… - Arthritis & …, 2016 - Wiley Online Library
Objective To analyze the methylome of normal and osteoarthritic (OA) knee articular
cartilage and to determine the role of DNA methylation in the regulation of gene expression …

Epigenetic differences in human cartilage between mild and severe OA

FC Moazedi‐Fuerst, M Hofner, G Gruber… - Journal of …, 2014 - Wiley Online Library
The development of osteoarthritis (OA) depends on genetic and environmental factors,
which influence the biology of the chondrocyte via epigenetic regulation. Changes within the …